The Effectiveness of Assisted Autogenic Drainage (AAD) and Intrapulmonary Percussive Ventilation (IPV) to Treat Hospitalized Infants (<2years) With Acute Viral Bronchiolitis: a Randomised Clinical Trial.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 103
- 试验地点
- 1
- 主要终点
- Length of Hospital Stay
研究概览
简要总结
The purpose of this study is to investigate the effectiveness of two airway clearance techniques; Intrapulmonary Percussive Ventilation and Assisted Autogenic Drainage in hospitalized infants under the age of 2 with acute viral bronchiolitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 1 Day 至 24 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •first period of wheezing
- •Wang score between 3 and 7
- •age < 24 months
- •Sa02> 90%
排除标准
- •ICU patients
- •mechanical ventilation
- •use of antibiotics
- •use of corticosteroids
- •gestational age < 34 weeks
- •chronic cardiac or pulmonary disease
- •no parental consent
研究组 & 干预措施
Intrapulmonary Percussive Ventilation
20 min of IPV administered to the patient inhalation 4ml hypertonic saline 3% 3x/day
干预措施: inhalation 4ml hypertonic saline 3% 3x/day (Other)
Intrapulmonary Percussive Ventilation
20 min of IPV administered to the patient inhalation 4ml hypertonic saline 3% 3x/day
干预措施: Intrapulmonary Percussive Ventilation (Device)
Assisted Autogenic Drainage
20 min of AAD administered to the patient inhalation 4ml hypertonic saline 3% 3x/day
干预措施: inhalation 4ml hypertonic saline 3% 3x/day (Other)
Assisted Autogenic Drainage
20 min of AAD administered to the patient inhalation 4ml hypertonic saline 3% 3x/day
干预措施: Assisted Autogenic Drainage (Procedure)
control
20 min of bouncing administered tot the patient inhalation 4ml hypertonic saline 3% 3x/day
结局指标
主要结局
Length of Hospital Stay
时间窗: 6 days
Previously publised data ( Luo et al. 2011) showed that the average hospital stay for infants with acute viral bronchiolitis, inhaling 4 ml NaCl3%, three times /day is 6 days ( SD 1,2)
次要结局
- Wang Score(before treatment, immediately after treatment and 1h after treatment)
- Heartrate(before, after and 1h after intervention)
- Oxygen Saturation (SaO2)(before, after and 1h after treatment)
研究者
Filip Van Ginderdeuren
PT,Drs
Vrije Universiteit Brussel