NL-OMON33571已完成2 期
Organ protection by noble gases - helium therapy in acute ischemic stroke - Helium in ischemic stroke
Gooi-Noord Ziekenhuis0 个研究点目标入组 20 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •age >= 18 years;
- •clinical anterior circulation ischemic stroke;
- •< 12 hours of witnessed symptom onset
- •National Institutes of Health Stroke Scale (NIHSS) score >= 4;
- •pre-admission modified Rankin scale (mRS, dutch version) <= 1;
- •Visual estimation of penumbra/infarct ratio > 20%
排除标准
- •eligible for rt-PA thrombolysis;
- •inability to obtain written informed consent;
- •legal incapacity
- •medically instable (blood pressure >230/120 or <100/60 mmHg, pulse > 120 bpm, mechanical ventilation needed, body temperature above 39*C)
- •intracerebral hemorrhage on admission non-enhanced CT;
- •rapidly improving neurological deficits;
- •impaired renal function (serum creatinin levels > 130 µmol/l)
- •allergic to contrast agent;
- •use of anticoagulation drugs or coagulopathy (PTT > 1.5 times control)
- •use following nephrotoxic medications: aminoglycosids, amfoterecine B or cisplatin
- •contra-indication or intolerance to any used substance;
研究者
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