An open labelled comparitive two arm prospective clinical study to eveluate the efficacy of nimbpatradi lep in vrana.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Nimbapatradi lep has wound healing potential as equal to betadine
研究概览
简要总结
Ayurveda is a holisticscience of life, health & cure committed to healing wholeness. Shalyatantra is one of theimportant branches of Ayurveda in which surgical and parasurgical techniques have been described for management of various surgical diseases.
In medical practice, healingof wound (vrana) in a short period of time is very important factor. Growingcivilization and today lifestyle we come across many such patients withvarieties of wound. Sometimes healing will not happen in a healthy way at woundsite and it takes lots of time for skin to regain its natural state. Eventhough healing of wound is a natural process of body, the vrana should beprotected from doshadushti and from various infections which may hamper thenatural rate of healing of wound. Vrana is the most important and widelydescribed chapter of ShalyaTantra by Acharya Sushruta. Sushruta is known formiscellaneous in surgical procedures. He has describedVrana in a very precise manner.
As the sciences advanced,newer therapies are tried out to boost up the recovery process but still theolder remedies lead the race. Acharya Sushruta explained vrana in detail in hisclassical book Sushruta Samhita. As concourse of wound healing proceduresdescribed by sushruta samhita still holds its place. Acharya Sushruta explainvarious kalpa for management of vrana. So in this study, we are highlightingone of the kalpana from Sushruta samhita.
Now a days, Betadine i.e.povidone iodine is used for cleaning and dressing of wound. It is an effectiveand useful germicide. It is widely used for dressing in wounds. However itsfrequent use is contraindicated because of it’s insolubility and its stainingand irritable properties.
Ayurvedic texts grant us theopportunity to treat wounds (Vrana) with cost effective medication instead ofsurgical procedure. Delayed healing in wound in main complain of patient ofvrana .As mentioned in Ayurvedic Samhitas ,Vrana is caused by both Nija &Agantujhetu. ‘ Nimbpatradi Lep’ is anideal formulation which shows Shodhan and Ropana effect causes wound healing . Hence it was decided to take upthis subject.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients Of age 18 to
- •Patients who will give consent for study .
- •Both Male and female 4)Patient with all types of Dushta vrana with maximum history of 1 month 5)Patient having clinical feature of Nija /Agantuj Dushta vrana i.e. foul smell, pus discharge ,pain, burning sensation will be selected for study 6)Wound less than or equal to 30 cm2 area.
- •Ulcer with depth = muscle deep.
排除标准
- •Patients suffering from systemic disease like uncontrolled Diabetes mellitus, Tuberculosis , CKD, Severe Anemia , Malnutrition were excluded from the study.
- •Patient suffering from grave condition likes malignant ulcer and other severe illness like HIV were excluded.
- •Wound Size greater than 30cm2 or Depth more than 1 cm 4)Following ulcer will be excluded Bone deep ulcer (Depth more than 1 cm ) Compound fractures Ischemic Ulcer.
结局指标
主要结局
Nimbapatradi lep has wound healing potential as equal to betadine
时间窗: 10 days
次要结局
- Nimbapatradi lep improves parameters like discharge foul smell etc in vrana(10 days)