NCT04510155已完成不适用
Liver Glycogen Dynamics and Substrate Oxidation in Lean Healthy Volunteers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Hepatic glycogen content
研究概览
简要总结
The purpose of this study is to investigate the effect of prolonged overnight fasting in the hepatic glycogen stores
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants are able to provide signed and dated written informed consent prior to any study specific procedures
- •Caucasian (people will be excluded when having a ≥50% racial African/Asian background)
- •Participants should have suitable veins for cannulation or repeated venipuncture
- •Women are post-menopausal (defined as at least 1 year post cessation of menses)
- •Men and women aged ≥ 45 and ≤ 75 years at the start of the study
- •Body mass index (BMI) 18.5 - 25 kg/m2
- •Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
- •Sedentary lifestyle (not more than 3 hours of vigorous sports per week)
排除标准
- •Type 2 Diabetes Mellitus
- •Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- •Any contraindication for MRI scanning
- •Alcohol consumption of >2 servings per day
- •Regular smoking
- •No use of medication interfering with investigated study parameters (as determined by responsible physician)
- •Participants who do not want to be informed about unexpected medical findings, or do not wish that their physician
结局指标
主要结局
Hepatic glycogen content
时间窗: 1 hour
Measured with 13C-MRS
次要结局
- Substrate oxidation(14 hours)
研究者
Charlotte Andriessen
Principal Investigator
Maastricht University
研究点 (2)
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