Targeting Endoplasmic Reticulum Stress to Correct Vascular Insulin Resistance and Glycemic Dysregulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Blood flow
研究概览
简要总结
The purpose of the present study is to determine if use of dietary supplement tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
详细描述
The notion that cellular stress lowers insulin-induced vasodilation is largely founded on ex vivo studies and experiments in rodents. However, it remains unknown if maintenance of cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances vascular function in humans. The investigators test the hypothesis that daily administration of this dietary supplement enhances vascular function, particularly, insulin-stimulated leg blood flow and glucose disposal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants are not told which are placebo or tauroursodeoxycholic acid capsules
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes diagnosed by primary physician
- •Body mass index less then 43 kg/m2
排除标准
- •Recent weight gain or loss (>5% body weight in the last 3 months)
- •Pregnancy
- •Consumption of >14 alcoholic beverages per week
- •Changes in the medication use or dose within the last 3 months
- •Known cardiovascular or pulmonary disease
- •Taking medication for advanced retinopathy or neuropathy
- •Taking prescription anticoagulants
- •Nicotine use
结局指标
主要结局
Blood flow
时间窗: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Blood flow response during insulin clamp
Insulin resistance
时间窗: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Glucose disposal rate during insulin clamp
Glucose tolerance
时间窗: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Glucose response to an oral glucose tolerance test
Vascular function
时间窗: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Flow-mediated dilation
次要结局
未报告次要终点
研究者
Jaume Padilla
Assistant Professor
University of Missouri-Columbia