L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients
试验速览
- 阶段
- 2 期
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- postoperative ammonia levels
研究概览
简要总结
L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients were those surgically treated for hepato-biliary diseases
排除标准
- •Patient exclusion criteria included a body weight loss greater than 10% during the six months prior to surgery, the presence of distant metastases, or seriously impaired function of vital organs due to respiratory, renal or heart disease.
研究组 & 干预措施
ordinary group
usual intake prior to liver surgery
干预措施: usual intake (Other)
carnitine group
treatment with oral L-carnitine, 1500 mg/body per day for 2 weeks prior to liver surgery
干预措施: L-carnitine (Drug)
结局指标
主要结局
postoperative ammonia levels
时间窗: 3 points; preoperative baseline, postoperative day 1, and day3
change from preoperative baseline at postoperative day 1 and day3
次要结局
- length of hospitalization after liver resection(up to 24 weeks)
研究者
Takehiro Okabayashi
Division Manager
Kochi University