Long-term Follow up of Patient With Anti-GABAbr Antibodies Associated-encephalitis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Modified-Rankin scale (mRS)
研究概览
简要总结
First described in 2010, GABA-B-receptor antibodies-associated encephalitis is a disease with a severe vital and functional prognosis. Indeed, functional status is mostly altered by encephalitis and it induced consequences while vital status is mostly engaged by cancer very often associated in the course of the disease, mostly small-cell lung cancer (SCLC).
While knowledge is growing on clinical features at each stage of the disease, long-term outcome data is still lacking even if known to be pejorative.
In this study, we aimed to describe long-term follow up of all patients who were diagnosed a GABAb-receptor antibodies-associated encephalitis in the French Paraneoplastic Neurological Syndrome Reference Center until now.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •encephalitis tested positive to GABAbr-antibodies after the examination of CSF samples tested for autoimmune encephalitis at the French Paraneoplastic Neurological Syndrome Reference Center from January 2011 to January 2022.
排除标准
- •tested positive to another onconeural antibody.
结局指标
主要结局
Modified-Rankin scale (mRS)
时间窗: At 60 month (after the beginning of the disease)
Modified-Rankin scale (mRS) ranked from 0 (full autonomy) to 6 (death)
次要结局
未报告次要终点