Functional MRI of Cognitive Control in Autism
试验速览
- 阶段
- 不适用
- 发起方
- UMC Utrecht
- 入组人数
- 90
- 试验地点
- 1
研究概览
简要总结
This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 6 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 6 - 12 years at inclusion
- •Inclusion criteria for subjects with autism
- •DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview
- •Inclusion criteria for controls
- •No DSM-IV (APA, 1994) diagnosis, according to DISC interview
- •No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
排除标准
- •Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
- •Presence of metal objects in or around the body (pacemaker, dental braces)
- •History of or present neurological disorder