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临床试验/NCT02441751
NCT02441751Unknown不适用

Intraoperative Repolarisation - Etiology and Relevance for the Decision Making by Anesthesiologists in the Management of Volume Substitution and Transfusion

Technische Universität Dresden1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2015年5月最近更新:
适应症

试验速览

阶段
不适用
入组人数
200
试验地点
1
主要终点
change in QT-time

研究概览

简要总结

QT interval changes is measured during all phases of the operation. The protocol is focusing at intraoperative bleeding events and is also observing QT interval changes during anesthetic and operative procedures.

详细描述

Prolongation of the QT interval is associated with functional torsade de points, re-entry, and sudden death (see reference). Variations of QT-interval caused by changes in the volume status of the patient during an operation remained unclear. QT interval changes will be monitored during the surgery with the focus of the influence of sudden blood loss, volume substitution by crystalloids, blood and blood products. The effect of surgical procedures on the QT-interval (e.g. clamping of kidney artery) will be observed as well as the association of intra-operative QT-interval alterations with postoperative complications.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • American Society of Anesthesiologists physical status classification 2 - 3
  • patients after consent

排除标准

  • Children,
  • pregnant women,
  • patients not able to consent

结局指标

主要结局

change in QT-time

时间窗: during operation

次要结局

  • survival(1 year)
  • postoperative incidents/disturbance rhythm of the heart(2 days)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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