Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Blood plasma levels of HDL-cholesterol
研究概览
简要总结
People with a spinal cord injury (SCI) characteristically have low levels of high-density lipoprotein-cholesterol (HDL-c; "good cholesterol") and high levels of low-density lipoprotein-cholesterol (LDL-c; "bad cholesterol"), and are at a higher risk of developing cardiovascular health problems, such as heart disease, heart attack and stroke, than the able-bodied population. A common way for able-bodied people to improve their lipid profile is through exercise; however, SCI people, especially tetraplegics, are often unable to achieve and maintain a level of exercise needed to obtain these benefits. It is therefore clinically important to find an effective, safe and inexpensive method of increasing HDL-c levels in people with chronic tetraplegia. This study will investigate the effects of omega-3 fatty acid supplementation on the lipid profile of people with tetraplegia. The investigators hypothesize that 5 months of daily consumption of high doses of omega-3 fatty acids will increase plasma levels of HDL-c in those with tetraplegia, leading to decreased risk of cardiovascular health issues.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having chronic tetraplegia (at least on year since injury)
- •18 years or older
- •Having below normal fasting blood plasma levels of HDL-c (<1 mmol/l)
排除标准
- •Currently taking omega-3 supplements
- •Currently taking medications for abnormal cholesterol
- •Having a heart attack or stroke in the past one year
结局指标
主要结局
Blood plasma levels of HDL-cholesterol
时间窗: Month 5
Change in blood plasma levels of HDL-cholesterol at month 5 compared to baseline levels
次要结局
- Blood plasma levels of total cholesterol(Month 5)
研究者
Dr. Karen Ethans
Director, Spinal Cord Rehabilitation Unit
University of Manitoba
