CHildhood ASthma and Environment Research Study - CHASER Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,660
- 试验地点
- 2
- 主要终点
- Asthma
研究概览
简要总结
"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.
The first phase - transversal study will identify determinants of pediatric asthma control
The second phase - longitudinal study, in patients with persistent asthma, will be focused on:
- predictors for asthma exacerbations and loss of control
- real life adherence to asthma therapy guidelines
- phenotypic characterization through the collection of saliva samples
- assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing
- evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis.
Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 5-16 years
- •not asthma
排除标准
- •chest deformity
- •active smoking
结局指标
主要结局
Asthma
时间窗: 5 years
次要结局
- Measures from saliva samples(5 years)
- Measures from nasal brushing(5 years)
- Measures from urine samples(5 years)
研究者
Stefania La Grutta, MD
Stefania La Grutta, MD. Senior Researcher. Coordinator of Pediatric Allergy and Asthma Research Group. Institute of Biomedicine and Molecular Immunology, IBIM, National Research Council of Palermo, Italy.
Istituto per la Ricerca e l'Innovazione Biomedica