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临床试验/NCT03075566
NCT03075566Unknown不适用

Clinical and Biochemical Markers in Coronary Artery Disease

Nadia Bouzidi, PhD1 个研究点 分布在 1 个国家目标入组 517 人开始时间: 2014年9月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
517
试验地点
1
主要终点
Biochemical parameters

研究概览

简要总结

Atherosclerosis is a chronic inflammatory condition, which is associated by the involvement of several pathological events, and alteration in the serum levels of pro- and anti-inflammatory, and lipid markers.

The investigators evaluated the contribution of serum biomarkers levels to the pathogenesis of coronary artery disease, namely their association with risk factors, clinical presentation, extent and severity of atherosclerotic changes accompanying coronary artery disease.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Coronary Artery Disease

排除标准

  • Severe respiratory disease
  • Liver disease
  • kidney disease
  • Inflammatory diseases (infections, autoimmune disorders, malignancy).

结局指标

主要结局

Biochemical parameters

时间窗: 1 Days

* Glucose (mmol/l), urae (mmol/l), creatinin (µmol/l), total cholesterol (mmol/l), high density lipoprotein cholesterol, HDL-C (mmol/l), triglycerides (mmol/l), lipoprotein(a) (g/l), apolipoproteins, apo (g/l) were measured only once in each patient at admission, before angiography and in each control group participant using the COBAS INTEGRA 400 chemical analyzer (Roche Diagnostic, Germany). * Troponin I (ng/ml), creatine kinase (CK) (UI/L), creatine kinase MB Isoenzyme (CK-MB)(UI/L), glutamic-oxaloacetic transaminase (ASAT) (UI/L) were measured using the COBAS INTEGRA 400 chemical analyzer (Roche Diagnostic, Germany). Only one measure was performed for each participant regarding all these parameters. * Light density lipoprotein cholesterol, LDL-C (mmol/l) was estimated using the Friedewald equation. Only one measure was performed for each participant. * Values which were out of the confidence range were considered as abnormal values.

Inflammatory markers

时间窗: 2 Days

* Serum Amyloid A (SAA) (mg/l) was measured using the BN Prospec, Siemens. * High sensitivity C reactive protein, hsCRP (mg/l) was measured using the COBAS INTEGRA 400 chemical analyzer (Roche Diagnostic, Germany). * Activin A (pg/ml) was quantified at 450nm using a commercially available ELISA kit (AbFrontier, Young In Frontier Co., Ltd, Korea). Only one measure was performed for each participant. * Interleukin-6 (pg/ml) was measured using a Cobas E601 analyzer (Roche Diagnostics, Germany). Only one measure was performed for each participant. * Values which were out of the confidence range were considered as abnormal values.

次要结局

未报告次要终点

研究者

发起方
Nadia Bouzidi, PhD
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Nadia Bouzidi, PhD

Bouzidi Nadia, PhD

University of Monastir

研究点 (1)

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