Comparison of Compact 3T, Conventional 3T, and 7T Scanners Using Task Based and Resting State fMRI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Statistical maxima of fMRI language and motor area activations.
研究概览
简要总结
Comparison of 3 MRI scanners.
详细描述
Comparing the strengths and weaknesses of 3 different MRI scanners in their performance of a functional MRI (an MRI that shows which areas in the brain are active during some sort of task).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and Women aged 18-55
排除标准
- •Patients with safety contraindications to MRI scanning at 3T.
- •Patients unable to adequately perform the fMRI task due to physical, neurological, or cognitive disability.
- •Patients that demonstrate 3 mm or greater translational head motion during scanning of the fMRI rhyming task data sets.
- •Pregnant women.
- •Patients that have implanted medical devices or other safety contraindications for a 7T or 3T MRI exam.
结局指标
主要结局
Statistical maxima of fMRI language and motor area activations.
时间窗: Approximately 6 months after last subject is scanned
For the task-based fMRI comparison, a region of interest will be drawn around activation maps overlying Broca's and Wernicke's language areas as well as the hand motor area. The data regarding each of the three regions will be treated separately. The statistical maxima for functional activation within these areas will be measured and compared using the same areas and technique on the three scanner platforms to determine which is the highest. This will be performed using the PRISM software we already use clinically to interpret fMRI.
Signal to noise ratio assessment of resting state.
时间窗: Approximately 6 months after last subject is scanned
For the resting state fMRI comparison, a standard measurement of signal to noise ratio will be employed specifically using the default mode network. This data will be reported separately from the task based outcome #1 as they are unrelated. Because this is a ratio is has no units of measurement.
次要结局
- Neuroradiologist preference for scanner array.(Approximately 6 months after last subject is scanned)
研究者
David F. Black
Principal Investigator
Mayo Clinic