Do Facial Expression Recognition Disorder and Mirror Neurons Subtend Apathy in Parkinson's Disease?
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Measurement of facial electromyographic activity during emotional facial expression recognition tests
研究概览
简要总结
After few years of evolution, patients with Parkinson's disease may develop apathy, with different degrees of severity. Apathy is characterized by a loss of interest for the others and for activities. The lack of social interactions in these patients may be due to an impairment in decoding emotional facial expression. Indeed, facial expression recognition, which is necessary to understand other's emotional state, requires a subclinical facial mimicking of the expression observed. Yet, one of the clinical signs of PD is amimia.
This study aims to determinate if there is a facial mimicry disorder in PD ( Parkinson's disease )patients with emotional facial expression (EFE) recognition impairment, compared to healthy control subjects. We also want to know if this facial mimicry disorder is primary (subtended by facial mobility impairment, that is to say amimia) or secondary (related to the mirror neuron systems that allows us to activate similar neural networks when observing and feeling a specific emotion)
详细描述
20 patients with an Idiopathic Parkinson's disease
+ 20 paired healthy volunteers (on sex, age, and education)
After inclusion, patients are evaluated two times: they are studied without medication (MED OFF) and with medication (STIM ON) in a randomized order. The 2 evaluations should be spaced out 15 days to one month (J0 and J+15d)
Healthy subjects have only one visit J0 (inclusion and emotional facial expression recognition tests are made at the same time)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with idiopathic Parkinson's disease according to UKPDSBB criteria - Men or women aged between 18 to 75 years
- •Free from any visio-perceptive disorder (visual acuity and Vitec)
- •Affiliated to National Health system
- •Having given their informed consent
- •-Healthy controls
- •Men or women aged between 18 to 75 years
- •Free from any visio-perceptive disorder (visual acuity and Vitec)
- •Affiliated to National Health system
- •Having given their informed consent
排除标准
- •With dementia or with significant dysexecutive disorder (MMS <24, MATTIS< 130)
- •With fluctuations (<5 Levodopa intakes / day)
- •With severe depression (BDI > 27)
- •With psychiatric comorbidities (hallucinations, psychos) evaluated with l'Unified Parkinson's disease Rating Scale part I (UPDRS part I =0)
- •With faces processing disorder (Benton < 39)
- •Treatment with deep brain stimulation
- •Under guardianship
- •In excluding period for another study
- •-Healthy controls
- •Suffering of neurological or psychiatric evolutive condition
- •With severe depression (BDI > 27)
- •With faces processing disorder (Benton < 39)
- •In excluding period for another study
结局指标
主要结局
Measurement of facial electromyographic activity during emotional facial expression recognition tests
时间窗: at J0 and at J+15 days
次要结局
- Measurement of facial electromyographic activity during voluntary facial mimicking(at J0 and at J+15days)
- Measurement of facial electromyographic activity during emotional movies viewing(Made at J0 and at J+15days)
- Measurement of Empathy (Baron-Cohen), Apathy (Starkstein)(Made at J0 and at J+15days)
- Measurement of the effect of Levodopa on these parameters(Made at J0 and at J+15days)