NCT00188045终止4 期
Hemodynamic Effects of Chronic Administration of Spironolactone, Propranolol and Their Association in Alcoholic Cirrhotic Patients
University Hospital, Angers0 个研究点目标入组 54 人开始时间: 1995年4月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- 入组人数
- 54
- 主要终点
- assessment of hepatic veinous pressure gradient changes after chronic treatment by spironolactone or propranolol alone or in association.
研究概览
简要总结
The aim of this study was assesment of splanchnic and systemic hemodynamic effects of chronic administration (2 month) of spironolactone or propranolol, alone or in association in alcoholic cirrhotic patients. The patients were randomized in 4 groups (aldactone 150 mg/day, propranolol 160 mg/day, aldactone 150 mg/day + propranolol 160 mg/day, placebo). Systemic and splanchnic hemodynamic effect were evaluated by hepatic venous pressure gradient measurements before and after 2 month of treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Indication of transjugular hepatic biopsy
- •alcoholic cirrhosis
- •presence of oesophageal varices ≤ stade 2
排除标准
- •renal insufficiency
- •natremia ≤ 135 mmol/l
- •vasoactive treatment in the last month before inclusion
- •hepatocellular carcinoma
- •positive HIV and HCV patients
- •paracentesis in the last week before inclusion
- •digestive bleeding in one last week
- •oesophageal varices stade 3 or 2 with red signs
结局指标
主要结局
assessment of hepatic veinous pressure gradient changes after chronic treatment by spironolactone or propranolol alone or in association.
次要结局
- Efficacy of spironolactone/propranolol association
研究者
相似试验
尚未招募
Unknown
Impact of systemic therapy on the serum vascular endothelial growth factor levels in patients with hepatocellular carcinoma after transarterial chemoembolizatiohepatocellular carcinomaJPRN-UMIN000053279Kitasato University School of Medicine300
进行中（未招募）
不适用
Clinical, Biochemical and Haemodynamic Effects of Large-volume Paracentesis (LVP) in Inflammatory SituationsParacentesisNCT02799160Charite University, Berlin, Germany22
已完成
4 期
Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS).Nfuence of Vasoactive Medication on Spinal OxygenationNCT03846765University Hospital, Ghent36
尚未招募
2 期
Comparision of effect of cisatracurium and vecuronium (both muscle relaxant) in a patient undergoing laproscopic appendicectomyCTRI/2019/05/019453Government medical college Bhavnagar
已完成
2 期
The investigation of hemodynamic effects of intravenous Ketamine after spinal anaesthesia for caesarean sectioDelivery by elective caesarean sectionanesthesia for cesarean delivery.IRCT201101293468N4Vice chancellor for research, Shahid Sadoughi University of Medical Sciences and Health Services60