National Swedish Study in Cushing´s Disease Incidence and Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 502
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
The purpose of this study is to study since 1987 all patients diagnosed with CD in Sweden and determine their outcomes including mortality. A secondary objective is to focus on patients in remission and identify determinants of their different outcomes.
详细描述
This study is a retrospective nationwide study of all patients in Sweden with diagnosis CD between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. This information as well as the exact diagnose criteria for each patient are going to be extracted by Endocrinologists in all University Hospitals in Sweden. An expert group at the Sahlgrenska University Hospital in Gothenburg will put together the data.By the use of the Swedish Personal Number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different Swedish Registers.
Primary aim:
To study mortality of CD in Sweden.
Secondary aims:
- To study the influence of CD on myocardial infarction
- To study the influence of CD on stroke
- To study the influence of CD on cancer
- To study the influence of CD on hip fracture risk
- To study incidence and prevalence of CD in Sweden.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients registered with Cushing's Disease in Sweden since 1987 in the statistical database for in- and out-patients, at the Swedish National Board of Health and Welfare will be included in the study.
排除标准
- 未提供
结局指标
主要结局
Mortality
时间窗: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years.
If event (death) has been occured during the observation period. Data obtained by the Swedish Cause Of Death Register (Swedish Board of Health and Welfare)
次要结局
- prevalence of Cushing's Disease in Sweden(Assessed up to 20 years.)
- influence of Cushing's Disease on myocardial infarction(From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years)
- incidence of Cushing's Disease in Sweden(Assessed up to 20 years.)
- influence of Cushing's Disease on stroke(From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years)
- influence of Cushing's Disease on hip fracture risk(From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years)
- influence of Cushing's Disease on cancer(From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years)