Serotoninergic Pathways in Sudden and Unexpted Death in Epilepsy (SUDEP)
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Density of Medullary 5-HT Neurons
研究概览
简要总结
The mortality rate is increased in patients with epilepsy, and especially among patients with drug-resistant epilepsy. This increased mortality is mainly related to the risk of SUDEP whose incidence is between 3.5 and 9 per 1,000 for patients with drug-resistant epilepsy. The term SUDEP refers to a sudden death occurring in a patient with epilepsy in whom anamnestic and post-mortem evidence does not identify a particular cause. Experimental and clinical data strongly suggest that most of SUDEP result from a postictal respiratory dysfunction progressing to terminal apnea. Due to the major role of serotonin in regulating breathing rhythms and data in animal models of epilepsy, it is envisaged that an alteration of serotonergic systems of the brainstem and limbic regions may play a central role in the occurrence of SUDEP. The objective of this work is to look for abnormalities of the serotonergic transmission within regulatory regions of respiratory and autonomic functions in brain samples prospectively collected in patients died from SUDEP.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years
- •Postmortem time before autopsy <30 hours
排除标准
- •Age <18 years
- •postmortem time before autopsy > 30 hours
- •Any subject whose brain would be of forensic interest
- •Any patient who expressed an opposition to organ donation.
结局指标
主要结局
Density of Medullary 5-HT Neurons
时间窗: between 1 to 30 hours following death
5-HT1A receptor binding density in within the medulla
次要结局
- Other markers of 5HT within the medulla(between 1 to 30 hours following death)
- Serotoninergic pathway in the pons, the hippocampus and the insula(between 1 to 30 hours following death)
- Catecholaminergic pathway(between 1 to 30 hours following death)