Effects of Railway Vibration on Sleep and Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Fasting insulin resistance in the morning immediately after the Control night
研究概览
简要总结
This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.
详细描述
The experimental sleep study has the overarching goal of deepening understanding of sleep disruption by railway vibration and noise and changes in cardiometabolic and cognitive function. To this end, the study will address the following study aim:
Aim 1: Determine the biological and neurobehavioral consequences of sleep disruption by railway vibration. The investigators will measure the sleep of healthy volunteers, and each morning will obtain blood samples for metabolomics metabolic function analysis and administer a neurocognitive test battery. The investigators will compare effects on sleep, metabolomics, metabolic function and cognitive function between quiet nights and nights with railway traffic vibration and noise. Dose-response relationships will be determined by comparing nights with different levels of vibration.
This study will take place in the sound environment laboratory (SEL) at the University of Gothenburg Department of Occupational and Environmental Medicine. The SEL is a high fidelity research laboratory equipped to simulate a typical apartment, including three individually light-, sound- and vibration-isolated private bedrooms. Ceiling mounted speakers in each room and electrodynamic transducers mounted to the underside of each bed allow the investigators to create a realistic acoustic environment by transmitting sound and vibration exposures from the control room to each bedroom individually. The investigators have shown previously that results from this lab with high ecological validity are comparable with results from the field.
This study has a prospective within-subjects cross-over design. Participants (total N=24) will each spend five consecutive nights in the SEL, with a sleep opportunity between 23:00-07:00. Daytime sleep will be prohibited, confirmed with measures of daytime activity via wrist actigraphy monitors worn continuously throughout the study. Three subjects will take part concurrently, in separate bedrooms. The first night is a habituation period to the study protocol and for familiarization with the test procedures. The second night will be a quiet condition without noise or vibration, to determine normal baseline sleep, cardiometabolic profile, and cognitive performance. Study nights 3-5 are the vibration nights and will be randomly assigned across participants using a Latin square design to avoid first-order carryover effects. In these vibration nights, vibration and noise from railway freight will be played into the bedrooms to determine the effects of vibration and noise on sleep, cardiometabolic function and cognitive performance. Thirty six trains will occur each night, randomly distributed across the 8-hour sleep period.
For railway vibration the investigators will use synthesized signals based on measured data, used in previous laboratory studies. It is necessary to use synthesized vibration, rather than recorded signals, so that the investigators can accurately adjust the acoustical character of the exposure as needed. Railway vibration will be accompanied by high fidelity recordings of railway freight noise. This is to maximize ecological validity of the exposures since vibration rarely occurs without noise, and to mask any mechanical sounds from the vibration transducers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participants will be aware that in any given study night they can be exposed to railway vibration and noise. They will not be informed what exposure condition will occur in any given night, but they can become unblinded to the exposure if they are awake, as they will may hear the noise or feel the vibration.
Study investigators responsible for analysing cognitive performance variables and physiological sleep data will be be blind to which vibration and noise interventions were introduced on which study nights.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1) live in or around the city of Gothenburg area (Sweden)
排除标准
- •aged <18 or >30 years;
- •habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00);
- •BMI>25 kg/m2;
- •regular sleep medication use (prescribed or "over-the-counter");
- •poor hearing acuity (measured during screening via pure tone audiometry);
- •diagnosed with sleep disorders;
- •diagnosed with diabetes
- •indications of sleep apnea on the STOP-BANG questionnaire;
- •shift work;
- •smoking, vaping, snus, or other nicotine use;
- •pregnant or breastfeeding
结局指标
主要结局
Fasting insulin resistance in the morning immediately after the Control night
时间窗: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Total sleep time during the intermediate vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the high vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Number of awakenings during exposure to high vibration
时间窗: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Total sleep time during the Control night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the Control night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the Control night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Fasting insulin resistance in the morning immediately after the intermediate vibration night
时间窗: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Total amount of N1 sleep during the low vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Fasting insulin resistance in the morning immediately after the low vibration night
时间窗: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Total sleep time during the low vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the low vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the intermediate vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Wakefulness after sleep onset (WASO) during the low vibration night
时间窗: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Wakefulness after sleep onset (WASO) during the intermediate night
时间窗: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Wakefulness after sleep onset (WASO) during the high vibration night
时间窗: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep efficiency during the intermediate vibration night
时间窗: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep depth assessed using the odds ratio product (ORP) during the low vibration night
时间窗: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Fasting insulin resistance in the morning immediately after the high vibration night
时间窗: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Total sleep time during the high vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the Control night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the Control night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the low vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the high vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the high vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Number of awakenings during exposure to intermediate vibration
时间窗: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Total amount of N2 sleep during the low vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the intermediate vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the high vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Sleep onset latency (SOL) during the intermediate vibration night
时间窗: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the high vibration night
时间窗: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep depth assessed using the odds ratio product (ORP) during the high vibration night
时间窗: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Sialic acid (GlycB) concentration after exposure to high vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to intermediate vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Total amount of N1 sleep during the intermediate vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the intermediate vibration night
时间窗: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Wakefulness after sleep onset (WASO) during the Control night
时间窗: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during the Control night
时间窗: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during exposure to low vibration
时间窗: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the Control Night
时间窗: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Area under the curve of odds ratio product (ORP) during exposure to railway vibration events, calculated using the trapezoid rule
时间窗: One night
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to low vibration night
时间窗: One
Determined from NMR analysis of blood plasma
Sleep efficiency during the low vibration night
时间窗: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep depth assessed using the odds ratio product (ORP) during the Control night
时间窗: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Sleep depth assessed using the odds ratio product (ORP) during the intermediate vibration night
时间窗: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
N-acetylglucosamine/galactosamine (GlycA) concentration after the Control night
时间窗: One night
Determined from NMR analysis of blood plasma
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to high vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after exposure to low vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after exposure to intermediate vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after the Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to high vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Sleep onset latency (SOL) during the low vibration night
时间窗: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep efficiency during the Control night
时间窗: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
S Sleep efficiency during the high vibration night
时间窗: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to intermediate vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after the Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Maximal change of odds ratio product (ORP) during exposure to railway vibration events
时间窗: One night
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
Sialic acid (GlycB) concentration after the Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to low vibration
时间窗: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to high vibration night
时间窗: One
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to Control night
时间窗: One
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after Control night
时间窗: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure toControl night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the control night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Lactic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the high vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Glucose concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Glucose tolerance in the morning after exposure to high vibration, assessed as glucose concentration 120 minutes after a glucose bolus
时间窗: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Dimethylsulfone concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the low vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Stumvoll Insulin sensitivity Index in the morning after control
时间窗: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Pyruvic acid concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to intermediate vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the intermediate vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Matsuda insulin sensitivity index in the morning after control exposure
时间窗: One night
Calculated as 10,000/square root of \[fasting glucose × fasting insulin\] × \[mean glucose × mean insulin during oral glucose tolerance test\])
D-Galactose concentration (mmol/L) after exposure to low vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to high vibration night
时间窗: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to Control night
时间窗: One night
Determined from NMR analysis of blood plasma
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the control night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Stumvoll Insulin sensitivity Index in the morning after exposure to low vibration
时间窗: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
时间窗: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Glucose tolerance in the morning after exposure to low vibration, assessed as glucose concentration 120 minutes after a glucose bolus
时间窗: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Glucose tolerance in the morning after exposure to intermediate vibration, assessed as glucose concentration 120 minutes after a glucose bolus
时间窗: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Glucose tolerance in the morning after Control night, assessed as glucose concentration 120 minutes after a glucose bolus
时间窗: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Stumvoll Insulin sensitivity Index in the morning after exposure to intermediate vibration
时间窗: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Matsuda insulin sensitivity index in the morning after exposure to low vibration
时间窗: One night
Calculated as 10,000/square root of \[fasting glucose × fasting insulin\] × \[mean glucose × mean insulin during oral glucose tolerance test\])
Matsuda insulin sensitivity index in the morning after exposure to high vibration
时间窗: One night
Calculated as 10,000/square root of \[fasting glucose × fasting insulin\] × \[mean glucose × mean insulin during oral glucose tolerance test\])
Stumvoll Insulin sensitivity Index in the morning after exposure to high vibration
时间窗: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Matsuda insulin sensitivity index in the morning after exposure to intermediate vibration
时间窗: One night
Calculated as 10,000/square root of \[fasting glucose × fasting insulin\] × \[mean glucose × mean insulin during oral glucose tolerance test\])
次要结局
- Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control(One night)
- Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration(One night.)
- Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration(One night)
- Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration(One night)
- Self-reported sleep disturbance by vibration after exposure to low vibration(One night)
- Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration(One night)
- Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration(One night)
- Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration(One night)
- Self-reported sleep disturbance by vibration after exposure to intermediate vibration(One night)
- Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration(One night.)
- Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration(One night.)
- Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control(One night)
- Self-reported sleep disturbance by vibration after control exposure(One night)
- Self-reported sleep disturbance by vibration after exposure to high vibration(One night)
- Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure(One night.)
- Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration(One night.)
- Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration(One night.)
- Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration(One night.)
- Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration(One night.)
- Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration(One night)
- Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure(One night.)
- Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration(One night.)
- Event-related cardiovascular activation in response to control(One night)
- Event-related cardiovascular activation in response to high vibration(One night)
- Evening neurobehavioural accuracy(One night)
- Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration(One night.)
- Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control(One night.)
- Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration(One night.)
- Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration(One night.)
- Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control(One night.)
- Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration(One night.)
- Event-related cardiovascular activation in response to low vibration(One night)
- Event-related cardiovascular activation in response to intermediate vibration(One night)
- Evening neurobehavioural speed(One night)