Plasma Expression Levels of MicroRNA-21 Might Help for Detection of HCV Patients Complicated by Hepatocellular Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Relation between MicroRNA and HCV
研究概览
简要总结
100 patients with diagnosed HCV were evaluated by clinical and ultrasound examination and were categorized as uncomplicated HCV (n=22) and complicated HCV (n=78). All patients were evaluated for hepatosteatosis and liver fibrosis using the computerized hepatorenal index, the hepatic steatosis index, aspartate aminotransferase (AST)/platelet count index (APRI) and the Fibrosis-4 (FIB-4) scores. Blood samples were obtained for estimation of serum levels of liver function tests and plasma levels of microRNA 21 and 126.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 31 Years 至 67 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Complicated hepatitis C by HCC
- •Complicated hepatitis C by liver cirrhosis
- •Complicated hepatitis C by steatohepatitis
- •uncomplicated hepatitis C
排除标准
- •pre-portal fibrosis secondary to previous bilharzial disease
- •pre-portal fibrosis secondary to alcoholic fatty liver
- •The presence of hepatic malignancy other than HCC
- •decompensated cirrhosis
- •hepatorenal failure
- •hepatic manifestations of congestive heart failure.
结局指标
主要结局
Relation between MicroRNA and HCV
时间窗: 12 months
The ability of estimation of plasma microRNA 21 and 126 to differentiate between uncomplicated and complicated HCV patients
次要结局
未报告次要终点
研究者
Amr M. El Hammady
Assistant professor of Internal Medicine
Benha University