Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)
研究概览
简要总结
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient 18 years and older
- •Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery
- •Patient able of accepting protocol information
- •Patient who received information about the protocol and had not expressed its opposition to participate
排除标准
- •Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI
- •Claustrophobic patient
- •Patients who cannot cooperate for the fMRI
- •Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
结局指标
主要结局
Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)
时间窗: 2 years
Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) to presurgically detect language areas located near a brain tumor
次要结局
- Langage laterality index obtained with both techniques (BOLD fMRI and fASL)and fASL)(2 years)
- Difference of cerebral blood flow maps obtained with ASL and fASL(2 years)