The Effect of Lifestyle Intervention on the Risk of Cancer - A Study of Participants in the Oslo Diet and Antismoking Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,216
- 主要终点
- Incidence of the group of cancers related to smoking, diet or body mass index
研究概览
简要总结
This study examines the effect of a five-year multifactorial lifestyle intervention in the Oslo diet and antismoking study on long-term cancer risk. In 1972-1973, 1232 men with high cardiovascular risk profile were randomised to intervention including cholesterol lowering diet, weight loss and antismoking advice, or control (1:1). This study examines the effect of the intervention on 43-year cancer incidence and mortality.
详细描述
The Oslo diet and antismoking study showed that a 5-year lifestyle intervention reduced the long-term risk of coronary events and mortality. The lifestyle risk factors for cancer are partly similar to those for coronary heart disease, e.g. smoking, high body weight, unfavourable diet. The investigators therefore expect that the intervention has an effect on cancer risk in the long term.
In this follow-up study, the investigators analyse the association between the intervention, and cancer incidence and mortality drawn from the Cancer Registry of Norway and the Norwegian Cause of Death Registry from the time of randomisation in 1972/3 until the end of 2015.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 49 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •participated in screening of coronary risk factors, into which all men born in 1923-1932 and living in Oslo were invited in 1972-1973
- •being in the upper quartile of a coronary risk score based on blood pressure, serum total cholesterol concentration and cigarette smoking
排除标准
- •serum total cholesterol level above 9.0 mmol per Liter
- •having a healthy diet, based on a short dietary history
- •self-reported cardiovascular disease or diabetes
- •previous history of cancer
结局指标
主要结局
Incidence of the group of cancers related to smoking, diet or body mass index
时间窗: 43 years
Diagnosis of carcinoma in the oral cavity, oropharynx, esophagus, stomach, colorectum, liver and intrahepatic bile ducts, pancreas, larynx, trachea, bronchus and lung, urinary tract and thyroid gland, drawn from the Cancer Registry of Norway
次要结局
- Mortality in the group of cancers related to smoking, diet or body mass index(43 years)
- Incidence of lung cancer(43 years)
- Incidence of prostate cancer(43 years)
- Cancer incidence(43 years)
- Incidence of gastrointestinal cancer(43 years)
- Cancer mortality(43 years)
- Incidence of urinary tract cancer(43 years)
研究者
Paula Berstad
Principal Investigator
Oslo University Hospital