Effects of Anemia on Sublingual Microcirculation in Patients Undergoing Goal-Directed Fluid Therapy: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 54
- 试验地点
- 1
研究概览
简要总结
The goal of this observational study is to learn about the effects of anemia on sublingual microcirculation in patients undergoing goal-directed fluid therapy (GDFT) during surgery. The main question it aims to answer is:
Does anemia, under the condition of goal-directed fluid therapy, lead to significant changes in sublingual microcirculatory parameters (such as microvascular density and perfusion)?
Participants will include 54 patients scheduled for elective open radical gastrectomy (27 anemic vs. 27 non-anemic). Sublingual microcirculation will be assessed using a side-stream dark field imaging device at four time points: before anesthesia induction (T0), after induction (T1), after specimen removal (T2), and after anastomosis completion (T3). All patients will receive intraoperative GDFT guided by pulse pressure variation (PPV) and cardiac output (CO) via the Vigileo-FloTrac system.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled for elective open radical gastrectomy
- •Age ≥ 18 years
- •ASA physical status I-III
- •Undergoing general anesthesia with endotracheal intubation
排除标准
- •Untreated ischemic heart disease or severe cardiovascular disease
- •Acute or chronic respiratory failure, severe asthma, pulmonary bullae, pneumothorax, emphysema, bronchopleural fistula
- •Oral or tongue disorders
- •Scheduled for laparoscopic surgery
- •Inability to position or observe the patient's head during surgery
- •Refusal to participate after entering the operating room
- •Intraoperative life-threatening events
- •Hemodynamic instability during surgery
研究者
Jun Zhang
Chief Physician of Anesthesiology
Fudan University