NCT03648814招募中不适用
Efficacy and Safety of Intracameral Versus Intravitreal Bevacizumab Injection as an Adjunctive Therapy Before Trabeculectomy With Mitomycin-C in Neovascular Glaucoma: A Prospective Randomized Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- regression of nevolascularization
研究概览
简要总结
To prospect studying the efficacy and safety of treating NVG with the intracameral versus the intravitreal injection of Bevacizumab.
详细描述
The present study comparing the safety and efficacy of 1.25mg/0.05mL Bevacizumab injection via the intracameral route versus the intravitreal route in treating the neovascular glaucoma
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of neovascular glaucoma
- •The patients having IOP > 21 mmHg, having the indication for trabeculectomy
- •The patients' age of at least 18-year-old
- •The patients having visual potential at least hand motion.
- •Present of NVI or NVA.
- •Willing and able to provide informed consent to participate in the study
- •Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits
排除标准
- •One eye patient
- •Patients having severe corneal edema or total hyphema obscure NVI or NVA view.
- •Cannot obtain endothelial cell count.
- •History of bevacizumab or fluorescence dye allergy.
- •Active infectious ocular disease including endophthalmitis and corneal ulcer
- •History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension
- •Has or planning to be pregnant or breastfeeding
结局指标
主要结局
regression of nevolascularization
时间窗: 2 months
Amount of nevolascular of iris and angle regression
次要结局
- Injection complication(2 days)
- IOP reduction(2 months)
研究者
Weerawat Kiddee
Assoc. Prof.
Prince of Songkla University
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Evaluation of the efficacy and safety of intravitreal injection of ranibizumab every other month for age-related macular degeneratioage-related macular degenerationJPRN-UMIN000005691Department of Ophthalmology, Shiga University of Medical Science40
已完成
不适用
Evaluation of the efficacy and safety of intravitreal bimonthly injection of aflibercept for age-related macular degeneratioage-related macular degenerationJPRN-UMIN000010312Department of Ophthalmology, Shiga University of Medical Science40
已完成
不适用
Intravenous sedation versus Inhalational sedation in day care minor oral surgical proceduresCTRI/2021/08/035723Gunti Natraj30
招募中
3 期
Comparison of Efficacy of Intravenous Versus Intramuscular Injection Meglumine Antimoniate in patients of Cutaneous LeishmaniasisIRCT20210823052264N4CMH Quetta90
招募中
2 期
Evaluation of Efficacy of intravenous magnesium sulphate with lidocaine 2% in preventing laryngospasm and postoperative pain after tonsilectomyIRCT20120915010841N22Hamedan University of Medical Sciences62