Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Stroke volume (ml)
研究概览
简要总结
The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)
排除标准
- •cardiovascular and/or pulmonary disease,
- •musculoskeletal disorders
- •medications that prevent the safe completion of the exercise protocol
结局指标
主要结局
Stroke volume (ml)
时间窗: 24 hours
measured using Physio Flow (non-invasive device)
Diastolic blood pressure (mmHg) by sphygmomanometer
时间窗: 24 hours
Measured from the brachial artery
Heart rate (bpm)
时间窗: 24 hours
measured using Physio Flow (non-invasive device)
Total peripheral resistance (mmHg/l/min)
时间窗: 24 hours
calculated: MAP (mmHg) / CO (l/min)
Mean arterial pressure (mmHg)
时间窗: 24 hours
calculated (MAP = (SBP-DBP)/3 + DBP
Systolic blood pressure (mmHg) by sphygmomanometer
时间窗: 24 hours
Measured from the brachial artery
Cardiac output (l/min)
时间窗: 24 hours
calculated: HR (bpm) x SV (ml)
次要结局
未报告次要终点