TCTR20200306004尚未招募3 期
The Effect of Early Initiation of SGLT2 Inhibitors in Reducing Heart Failure Events After MI
Faculty of Medicine, Chiang Mai University0 个研究点目标入组 476 人开始时间: 2020年3月6日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 476
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 35 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •1.Male or female patients ≥ 35 years of age
- •2.Diagnosis of ACS based on the 4th universal definition between 24 hours and 10 days before treatment allocation
- •3.LVEF ≤ 40% after index MI or
- •4.LVEF > 40% with symptomatic heart failure requiring iv diuretic or elevate natriuretic peptides NT-proBNP ≥ 600 pg/ml, if atrial fibrillation or flutter ≥ 900 pg/ml with Killip class II to IV
- •5.Hemodynamic stable defined as SBP ≥ 100 mmHg at initiation of treatment, no symptomatic hypotension
- •6.No increase in intravenous diuretics
- •7.No intravenous inotrope or intravenous vasodilators
- •8.Received revascularization to IRA with PCI
排除标准
- •1.Cardiogenic shock within last 24 hours prior to the screening
- •2.Planned CABG or cardiac surgery within next 3 months
- •3.Symptomatic hypotension at screening
- •4.Stroke or TIA 1 month prior to the screening
- •5.History of bladder cancer or history of radiation therapy to the lower abdomen or pelvis at any time
- •6.Impaired renal function, defined as GFR < 30 ml/min (MDRD formula) at screening
- •7.Diagnosis of Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA)
- •8.Life expectancy < 1 year
- •9. Prior diagnosis of heart failure
研究者
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