Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Blood flow
研究概览
简要总结
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy women,
- •Assigned female at birth,
- •18-70 years of age,
- •Body mass index <18 or ≥30 kg/m2,
排除标准
- •Assigned male at birth,
- •Pregnancy,
- •Breastfeeding,
- •History of hormone replacement therapy, chemical menopause, or oophor-ectomy
- •Polycystic ovarian syndrome or Primary ovarian insufficiency,
- •Current smoking/Nicotine use,
- •Blood pressure ≥140/90 mmHg,
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy,
- •Nerve/neurologic disease,
- •Cardiovascular, hepatic, renal, respiratory disease,
- •Hypersensitivity to nitroglycerin,
- •Diabetes,
- •Communication barriers,
研究组 & 干预措施
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
干预措施: Gemtesa (Drug)
Flow Mediated Dilation
Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.
干预措施: Placebo (Drug)
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
干预措施: Placebo (Drug)
Flow Mediated Dilation
Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.
干预措施: Gemtesa (Drug)
结局指标
主要结局
Blood flow
时间窗: Change from baseline to minute 2.
Blood flow measured with Doppler ultrasound.
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia