Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 166
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate per initiated ART cycle
研究概览
简要总结
Does prolonged GnRH downregulation prior to ART improve the clinical pregnancy rate in postoperative endometriosis patients? (A single centre randomised controlled trial)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •histologically proven endometriosis with complete treatment of all endometriosis lesions during laparoscopy
- •only first three ART cycles
- •normal uterine cavity
- •Eligible for ovarian stimulation with long agonist protocol
排除标准
- •FSH>20 IU/L
- •presence of large intramural fibroids (> 3 cm)
- •<4 oocytes obtained in any previous fresh ART cycle
- •ART with sperm derived from testicular biopsy
- •ART with Preimplantation Genetic Diagnosis/Screening
研究组 & 干预措施
oral oestroprogestogen pre-treatment
preparation with oral oestroprogestogens prior to downregulation in an assisted reproductive technology treatment (ART) cycle
干预措施: ethinylestradiol + dienogest (Drug)
gonadotropin-releasing hormone (GnRH) pre-treatment
preparation with gonadotropin-releasing hormone (GnRH) analogues prior to downregulation in an assisted reproductive technology treatment (ART) cycle
干预措施: triptorelin (Drug)
结局指标
主要结局
clinical pregnancy rate per initiated ART cycle
时间窗: participants will be followed for the duration of the ART cycle including the pregnancy test, an expected average of 10 weeks in the active comparator group and an expected average of 18 weeks in the experimental group
次要结局
未报告次要终点