Latent Toxoplasmosis in Females With Borderline Personality Disorder - Occurrence, Clinical Features, and Impact on Effectiveness of Combined Pharmacotherapeutic and Psychotherapeutic Treatment
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Immunoglobulin A detection in human serum
研究概览
简要总结
Borderline personality disorder is a common mental disorder with core features of affective dysregulation, impulsivity, and identity disturbance. Although this disorder is mostly understood as a result of a combination of biological factors (genes, temperament) and early aversive experiences (often of traumatic nature), recent data suggest that other factors may be important in its development and course. Preliminary findings show that patients with borderline personality disorder have higher prevalence of Toxoplasma seropositivity. This infection may manifest in symptoms such as affective dysregulation, aggression, suicidality, or anxiousness. As such, it may play a role in the psychopathology of the borderline personality disorder. The aim of this study is to explore the prevalence of Toxoplasma seropositivity in a sample of females with borderline personality disorder, its clinical correlates, and a potential impact on outcomes of an intensive six-week inpatient schema-therapeutic treatment. Results may enrich our understanding of this disorder and lead to improvements of the therapeutic approaches.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Borderline personality disorder diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders-5 criteria
- •Signed informed consent
排除标准
- •Current substance abuse disorder
- •Psychotic disorder, bipolar disorder, organic mental disorder current or past
- •Severe suicidal risk
- •Severe somatic illness (e.g., endocrinopathy, oncologic, hematologic, cardiologic, or neurologic illness)
研究组 & 干预措施
Females with borderline personality disorder
干预措施: Combined schema-therapy and cognitive behavioral therapy (Behavioral)
Females with borderline personality disorder
干预措施: Psychopharmaceuticals (Drug)
结局指标
主要结局
Immunoglobulin A detection in human serum
时间窗: 1 day
ELISA detection of immunoglobulin A specific antibodies - a sensitive and specific marker of acute infection. Index of positivity is higher than 1,1.
Immunoglobulin M detection in human serum
时间窗: 1 day
ELISA detection of immunoglobulin M specific antibodies - a highly sensitive marker of acute infection. Index of positivity is higher than 1,1.
Immunoglobulin G detection in human serum
时间窗: 1 day
ELISA detection of immunoglobulin G specific antibodies - a marker of undergone infection. The cut-off score for positivity is set at higher than 6,6 IU/ml.
Severity of borderline personality symptoms
时间窗: 1 year
Assessed by modified Clinical Global Impression for borderline personality disorder which was developed by Pérez et al (2007). This rating scale measures severity of the nine diagnostic criteria of the disorder, along with its overall severity. In each item, a clinician chooses one number of a seven-point scale where 1 = normal, not at all ill and 7 = among the most extremely ill subjects. The scores in the items are not summed. Instead, each of the item enters statistical analyses separately.
次要结局
- Beck Depression Inventory-II(1 year)
- Dissociative Experiences Scale(1 year)
- Sheehan Disability Scale(1 year)
- Borderline Evaluation of Severity over Time(1 year)
- Aggression Questionnaire(1 year)
- Suicide Behaviors Questionnaire-Revised(1 year)
- Beck Anxiety Inventory(1 year)
研究者
Marie Ociskova
Assistant Professor
Palacky University