Reduced Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease -Relevance of Cardiovascular Comorbidities
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
研究概览
简要总结
In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.
详细描述
In patients with chronic obstructive pulmonary disease (COPD) the interpretation of dyspnoea also needs to consider coexisting cardiovascular disease. Cardiopulmonary exercise testing (CPET) is used to characterize pulmonary and cardiac function and limitations during exercise. The investigators hypothesise that cardiopulmonary exercise is reduced in COPD patients with coexisting cardiovascular disease as well as in more symptomatic patients and in patients with frequent exacerbations. For this purpose, 100 patients with with stable COPD are characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with stable chronic obstructive pulmonary disease, exacerbated or stable
- •40-80 years
- •sinus rhythm
- •informed written consent
排除标准
- •Inability to give written consent
- •acute myocardial infarction with ST-segment elevations in last 30 days
- •severe acute or chronic renal dysfunction
- •severe heart failure-
- •atrial fibrillation
- •severe valve disease
- •severe hypoxemia
- •long term oxygen therapy or non invasive ventilation
结局指标
主要结局
Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
时间窗: Baseline
次要结局
- Measurement of Maximum wattage during cardiopulmonary exercise testing(Baseline)
- Measurement of FEV1(Baseline)
- Presence of cardiovascular comorbidities(Baseline)
- N-terminal pro brain natriuretic peptid (NTproBNP) in ng/L from peripheral venous blood at baseline(Baseline)
- measurement of dyspnoea quantified by the COPD assessment test as well as the modified Medical Research Council Scale(Baseline)
- Measurement of Breathing reserve during cardiopulmonary exercise testing(Baseline)
- Measurement of Oxygen pulse during cardiopulmonary exercise testing(Baseline)
- Measurement the capillary pO2 in mmHg and capillary pCO2 at baseline(Baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator
Heinrich-Heine University, Duesseldorf