Prospective Study for Prognostic Biomarkers of Nasopharyngeal Carcinoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Failure-free Survival
研究概览
简要总结
The purpose of this clinical research project is to explore potential biomarkers and validate the predictive and prognostic value of molecular signature in nasopharyngeal carcinoma.
详细描述
Objectives:
Primary: Evaluation of failure-free survival after three years of patients of nasopharyngeal carcinoma.
Secondary: Evaluation of overall survival after three years of patients of nasopharyngeal carcinoma.
Outline: This is a multicenter observational study. Tumor tissue specimens are obtained from the Sun Yat-sen University Cancer Center and Affiliated Hospital of Guilin Medical University. The samples are analyzed for biomarkers. The biomarkers are correlated with clinical outcomes (failure-free survival, overall survival, tumor response to treatment, distant metastasis, recurrence and death).
The aim of the analysis is to explore potential biomarkers and validate the predictive and prognostic value of molecular signature in nasopharyngeal carcinoma. This will lead to the definition of risk groups and stratification of patients and will help to precision medicine of nasopharyngeal carcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with newly histologically confirmed nasopharyngeal carcinoma
- •No evidence of distant metastasis (M0)
- •Written informed consent
排除标准
- •Treatment with palliative intent
结局指标
主要结局
Failure-free Survival
时间窗: 3 years
次要结局
- Overall Survival(3 years)
研究者
Jun Ma, MD
Prof
Sun Yat-sen University