Outcomes Using MARS: A Single Center Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Transplant free survival mortality
研究概览
简要总结
Retrospective chart review will be conducted on patients at Methodist Dallas Medical Center, meeting the inclusion criteria from January 1, 2019 to December 15, 2020 to determine the transplant free survival and overall survival and other secondary outcome measures.
详细描述
Retrospective chart review will be conducted on patients at Methodist Dallas Medical Center, meeting the inclusion criteria from January 1, 2019 to December 15, 2020 to determine the transplant free survival and overall survival and other secondary outcome measures. Patient's charts will be accessed on EPIC by the PI or delegated study personnel. The investigator's anticipate completion of this study by January 31, 2022.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient was diagnosed with: Alcoholic hepatitis; AoCLF; OR Acute fulminant liver failure
- •The patient underwent at least one round of dialysis using plasma exchange or MARSTM
排除标准
- •Patient not meeting the inclusion criteria will be excluded.
- •All patients who underwent MARS at MDMC will be included in the study population.
结局指标
主要结局
Transplant free survival mortality
时间窗: Rate at 30 days
transplant will be measured by date of death, and discharge
Improvement in Transplant
时间窗: Rate at 30 days
Determine whether treatment with MARS can help facilitate improvement in HE, LOS, and ICU duration.
Difference in Demographics
时间窗: Rate at 30 days
co-morbidities, etiology of liver failure between those treated with MARS vs. controls
次要结局
- Demographics(January 1, 2019 to January 31, 2022)
- Hepatorenal syndrome((in hospital [date of death or discharge or transplant]) and at 30 days)
- Need for vasopressor support((in hospital [date of death or discharge or transplant]) and at 30 days)
- Sepsis (as measured by by QSOFA criteria):((in hospital [date of death or discharge or transplant]) and at 30 days)
- ICU duration(date of ICU admission and date of discharge (or death))
- Need for CRRT as documented in the chart:((in hospital [date of death or discharge or transplant]) and at 30 days)
- long term dialysis((in hospital [date of death or discharge or transplant]) and at 30 days)