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临床试验/NCT05313126
NCT05313126Unknown不适用

Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts

Institut de Recherche pour le Developpement1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2021年11月9日最近更新:
适应症

试验速览

阶段
不适用
入组人数
500
试验地点
1
主要终点
Immunological indicators

研究概览

简要总结

This trial is based on 2 complementary components, named ExpAlbo Biomarker and CAPAlbo Questionnaire

  1. ExpAlbo Biomarker (Exposure to the Aedes albopictus mosquito): This component concerns the epidemiological evaluation of the effectiveness of the release of sterile male mosquitoes on the level of exposure of individuals to the bites of the tiger mosquito through the use of a new immunological biomarker of the human-vector contact, developed over the past 20 years by the IRD-MIVEGEC team. Indeed, when a person is bitten by a mosquito, he or she develops a defence reaction, called an immune reaction, against the mosquito's saliva. The main objective of this study is to measure this immune response, and more specifically the antibody response specifically directed against compounds (peptide = small fragment of a protein) in mosquito saliva, and to determine whether this anti-saliva antibody response, and therefore exposure to mosquito bites, decreases when the mosquito control strategy is applied.
  2. CAPAlbo Questionnaire: This component is concerned with assessing the impact of sterile male mosquito releases on perceptions and practices related to exposure to Aedes albopictus based on population-based questionnaire surveys. The main objective of these surveys is to determine whether changes in objective exposure to Aedes albopictus mosquitoes are associated with changes in the perception of the nuisance and in the lifestyle habits of respondents, particularly those related to the prevention of mosquito bites (such as the use of repellents or mosquito nets).

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • To inhabit on a regular basis in the intervention/control area
  • To speak French

排除标准

  • 未提供

结局指标

主要结局

Immunological indicators

时间窗: 12 months

Biomarker based on the measurement of human IgG antibody levels specific to one peptide of Aedes saliva (i.e. Nterm-24kDa salivary peptide)

Exposure to Aedes mosquito

时间窗: 12 months

self-perceived exposure to mosquito will be assessed by questionnaire

次要结局

  • Protective behavior(12 months)

研究者

申办方类型
Other Gov
责任方
Sponsor

研究点 (1)

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