Effect of AURICULAR Vagus Nerve Stimulation on Glucose Tolerance, and Mood States in Obesity
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Glucose tolerance.
研究概览
简要总结
Avoid unhealthy foods, walk every day for at least 15 min , sleep well, he should take sessions at its time, family should Avoid disturbances, keep quiet as much as possible, make Analysis recoired before and after interaction.
详细描述
Pre and post Anthrompometric measurement,waist circumference, body composition, lab tests, mood assessment, tVNS application, data management will be carried out using SPSSv26.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
Sham tVNS for 45 min 3 times per week in addition to dietary advices for 3 months .
入排标准
- 年龄范围
- 40 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •40_50years Both sexes , BMI more than or equal 30 kg/m2 FBG less than 7 mmol/l 2hpp between 7.8 and 11.1mmol/l at the time of enrollment . HOMA-IR >2.9 All are sedentary level activities.
排除标准
- •Diagnostic type 1and 2 DM Cardiovascular disease, stroke, uncontrolled hypertension Use psychoactive drugs, antiepliptic drugs, antidepressants. Present of metal implants, pace maker or cochlear implants. History of epilepsy or seizours . Pregnancy or breast feeding. Dermatologist condition near stimulating site. Major psychiatric disorders.
结局指标
主要结局
Glucose tolerance.
时间窗: Baseline and after 12th weeks of intervention.
Change in glucose tolerance assessed using 2\_hours oral glucose tolerance test (OGTT), expressed as glucose plasma area under curve (AUC), following a75 g oral glucose load.
次要结局
- Insulin resistance.(Baseline and after 12th weeks of intervention.)
- Insulin sensitvity.(Baseline and after 12th weeks of intervention.)
研究者
Enas Wagdy Elsaid Ahmed
Effect of auricular vagus nerve stimulation on glucose tolerance, and mood states in obesity
Cairo University