跳至主要内容
临床试验/NCT06280521
NCT06280521尚未招募不适用

Validation en Langue française du Girls Questionnaire for Autism Spectrum Condition (fGQ-ASC) Chez Des Femmes Adultes

University Hospital, Grenoble0 个研究点目标入组 400 人开始时间: 2024年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
400
主要终点
VP fGQ-ASC

研究概览

简要总结

Autism spectrum disorders (ASD) are currently diagnosed at a rate of approximately 3 males per 1 female, while evidence suggests the rate may be 1.8 males per 1.2 females. It has been shown that affected women receive an autism diagnosis on average 5 years later than men. This delay is associated with deleterious consequences on the educational, psychological and physical health levels in these women. Currently, there are a number of obstacles that delay or prevent women with ASD from accessing diagnosis and specialized support. These include, in particular, gendered assumptions about how ASD manifests depending on the gender of the person concerned, a tendency for clinicians to attribute female autistic traits to causes other than ASD, measures of standardized ASD assessments that may not be sensitive enough to identify ASD females, and finally a demonstrated greater tendency among ASD females to camouflage or mask autistic traits in order to blend in in social situations. It is in this context that the Girl Questionnaire for Autism Spectrum Conditions (GQ-ASC) was developped and validated to address these fundamental gaps in the early identification and measurement of female ASD symptoms.

The GQ-ASC is presented as a self-questionnaire with 29 items which assess clinical characteristics specific to the adult female presentation of ASD in the dimensions (five) of imagination and play, camouflage, sensoriality, social situations and interests. To date, several studies have relevantly used the GQ-ASC in populations of adult ASD women, but none in French.

The main objective of this online study is therefore to measure the predictive validity of the French version of the Girl Questionnaire for Autism Spectrum Conditions (fGQ-ASC) for the diagnosis of ASD in adult women over 18 years of age and speaking French kindergarten. Subjects included in this online study will complete the protocol using any computer, tablet, or cell phone. We will include 400 participants (100 females-ASD, 100 females-nonASD, 100 males-ASD, 100 males-nonASD). This study will validate for the first time a screening tool for the diagnosis of ASD in women of French mother tongue over 18 years of age (the Girls Questionnaire for Autism Spectrum Condition French version - fGQ-ASC). This tool will have particularly significant benefits since it will help reduce the diagnostic delay among adult women with ASD in France and accelerate their access to specialized support.

详细描述

CONTEXT AND JUSTIFICATION OF THE RESEARCH Autism spectrum disorders (ASD) are currently diagnosed at a rate of approximately 3 males per 1 female, while evidence suggests the rate may be 1.8 males per 1.2 females. It has been shown that affected women receive an autism diagnosis on average 5 years later than men. This delay is associated with deleterious educational, psychological and physical health consequences in these women (Rynkiewicz & Łucka 2018).

Currently, there are a number of obstacles that delay or prevent women with ASD from accessing diagnosis and specialized support. These include, in particular, gendered assumptions about how ASD manifests depending on the gender of the person concerned, a tendency for clinicians to attribute female autistic traits to causes other than ASD, measures of standardized ASD assessments that may not be sensitive enough to identify ASD females, and finally a demonstrated greater tendency among ASD females to camouflage or mask autistic traits in order to blend in in social situations.

It is in this context that Attwood and colleagues (2011) developed the Girl Questionnaire for Autism Spectrum Conditions (GQ-ASC) to address these fundamental gaps in the early identification and measurement of female ASD symptoms. . In order to specifically and reliably assess the presentation of ASD in affected women, the initial stages and item development of this questionnaire were constructed and generated from the authors' extensive clinical expertise (Attwood et al. 2011). as diagnosticians. The questionnaire was then validated in English in adult women with ASD through rigorous analyzes (Brown et al. 2020).

The GQ-ASC is presented as a self-questionnaire with 29 items to be rated on a 4-point Likert scale (1 = Completely disagree, 2 = Mostly disagree, 3 = Mostly agree, 4 = Completely agree. agree) which assess clinical characteristics specific to the adult female presentation of ASD in the dimensions (five) of imagination and play, camouflage, sensoriality, social situations and interests. The original English version of the GQ-ASC makes it possible to identify 80.0% of women with ASD based on a cut-off score. This self-questionnaire also presents robust psychometric properties, including significant correlations between the five dimensions measured and with other questionnaires assessing ASD (Brown et al., 2020).

To date, several studies have relevantly used the GQ-ASC in populations of adult ASD women, but none in French. We make the main hypothesis that the French version of this questionnaire (fGQ-ASC) presents good predictive validity for the diagnosis of ASD in adult women over 18 years old and of French mother tongue. We also formulate the following hypotheses: 1) the fGQ-ASC presents poor predictive validity for the diagnosis of ASD in adult men over 18 years of age and of French mother tongue, 2) the fGQ-ASC scores are significantly higher higher in these women than in non-ASD women, ASD men and non-ASD men, 3) the fGQ-ASC presents satisfactory psychometric characteristics in adult ASD women over 18 years old and native speakers French.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All groups: 18 years or older, French mother tongue
  • ASD groups: have a diagnosis of ASD without intellectual development disorder (intellectual disability) made by professionals trained in autism
  • Non-ASD groups: absence of diagnosis of psychiatric, neurological or neurodevelopmental disorder (including ASD made by professionals trained in autism), absence of suspicion of autism Secondary

排除标准

  • participant's wish to abandon the study currently being carried out.

结局指标

主要结局

VP fGQ-ASC

时间窗: baseline

The main objective of this study is to measure the predictive validity of the French version of the Girl Questionnaire for Autism Spectrum Conditions (fGQ-ASC) for the diagnosis of ASD in adult women over 18 years old and of French mother tongue.

次要结局

未报告次要终点

研究者

发起方
University Hospital, Grenoble
申办方类型
Other
责任方
Sponsor

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