Fentanyl Test Results and Its Association With Morphine Requirements in Children With Obstructive Sleep Apnea Syndrome After Adenotonsillectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Rescue Morphine Requirement
研究概览
简要总结
The purpose of this study is to discuss the relationship between the result of fentanyl test and required dosage of morphine for children with OSAS after adenotonsillectomy；and to evaluate the ability of predicting requested dosage of morphine postoperatively.
详细描述
All the patients were intubated. Sevoflurane was used for maintenance without any opioids. Before the end of the procedure, spontaneous respiratory was recovered. All the patients were given 1 mcg/kg fentanyl i.v. after the end of the procedure. The positive result was defined as spontaneous respiratory rate decreased more than 50%, the others were defined as negative result. All the patients were given morphine for pain relief according to our protocol after extubation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •meet all of the following
- •the American society of anesthesiologists (ASA) class Ⅰ ~ Ⅱ
- •the age of 3 ~ 7 years old
- •children who underwent selective adenotonsillectomy.
排除标准
- •meet anyone of the following
- •craniofacial malformations
- •mental retardation
- •BMI > 22 kg/m2
- •a history of bronchial asthma
- •a recent history of opioid use.
结局指标
主要结局
Rescue Morphine Requirement
时间窗: average 1 hour from extubation
次要结局
- Number of Participants With Pulse Oxygen Saturation Less Than 95 Percent(average 1 hour from extubation)
- Post-operative Nausea and Vomiting(average 1 hour from extubation)
研究者
Xuan Wang
Doctor
Children's Hospital of Fudan University