Cannabinoids, Learning, and Memory
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Rey Auditory Verbal Learning Test (RAVLT)
研究概览
简要总结
The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.
详细描述
This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged 18 and 55 years (extremes included) on day of first dosing
- •Exposed to cannabis at least once in their lifetime
排除标准
- •Cannabis naive
- •Positive pregnancy screen during screening
- •Hearing deficits
研究组 & 干预措施
Placebo
Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.
干预措施: Placebo (Drug)
THC
Active THC (0.0015mg/kg-0.03mg/kg) administered over 20 minutes.
干预措施: THC (Drug)
THC
Active THC (0.0015mg/kg-0.03mg/kg) administered over 20 minutes.
干预措施: Placebo (Drug)
Placebo
Control: small amount of alcohol intravenously (quarter teaspoon), with no THC over 20 minutes.
干预措施: THC (Drug)
结局指标
主要结局
Rey Auditory Verbal Learning Test (RAVLT)
时间窗: +35 minutes after infusion
a measure of verbal episodic memory
N-Back Task
时间窗: +65 minutes after infusion
a measure of working memory
次要结局
- Clinician Administered Dissociative Symptoms Scale (Total Score)(Baseline, +10, +85, and +240 minutes after the first infusion)
- Visual Analog Scale (Total Score)(Baseline, +10, +85, +240 minutes after the first infusion)
研究者
Mohini Ranganathan
Associate Professor
Yale University