Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 35,000
- 试验地点
- 1
- 主要终点
- Progress of aortic regurgitation
研究概览
简要总结
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
详细描述
Aortic regurgitation is relatively common, with a prevalence of 13% for men and 8,5% for women in the Framingham study (Singh et al). Patients with aortic regurgitation are evaluated regularly with echocardiography to see if progress occurs, and suitable candidates are referred for surgical repair or replacement of the aortic valve.
However, an American study from 2019 showed that only 12% of cases of aortic regurgitation progressed from mild to moderate or severe over a 10 years period (Yang et al). This means that the majority of patients undergo echocardiographic evaluations without a clinical benefit.
It is unclear whether these findings also apply to a Swedish population with the European definitions for aortic regurgitation.
Aim:
To do a retrospective analysis of patients evaluated with echocardiography in Västerås, Sweden between January 2003 and March 2025 to describe the prevalence of aortic regurgitation as well as aortic dilatation, to describe how often progress occurs in patients with mild or moderate aortic regurgitation, and finally to look at factors (clinical, echocardiographic) associated with progress of aortic regurgitation as well as outcome (mortality, MACE, cardiac surgery).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients investigated with echocardiography between January 2003 and March 2025
- •Age ≥18 years
- •At least minimal aortic regurgitation
- •At least one additional echocardiography after the index investigation
排除标准
- •Age <18 years
结局指标
主要结局
Progress of aortic regurgitation
时间窗: Depending on when the patients was evaluated first, up to approximately 20 years of follow-up
Progress of aortic regurgitation from mild to moderate or severe, or moderate to severe. Progress is defined according to current European Society for Cardiology guidelines using a comprehensive echocardiographic assessment
次要结局
- Surgical treatment of aortic regurgitation or aortic aneurysm(Depending on when the patients was evaluated first, up to approximately 20 years of follow-up)
- Hospitalization for heart failure(Depending on when the patients was evaluated first, up to approximately 20 years of follow-up)
- Hospitalization for stroke or myocardial infarction(Depending on when the patients was evaluated first, up to approximately 20 years of follow-up)
- All-cause mortality(Depending on when the patients was evaluated first, up to approximately 20 years of follow-up)
研究者
Pär Hedberg
Associate professor
Region Västmanland