Clinical study of Hanbi ointment in the treatment of rheumatoid arthritis

The First Affiliated Hospital of Yunnan University of traditional Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1. Patients meeting the ACR / EULAR diagnostic criteria for RA in 2010;
•2. Patients who meet the diagnostic criteria of traditional Chinese medicine syndromes of Bi cold dampness obstruction syndrome;
•3. Subjects aged between 18 and 70 years, regardless of gender;
•4. For the subjects whose X-ray staging of the joints of both hands belongs to stage I and II, the joint function classification belongs to grade I, II and III;
•5. 2.6 < DAS28 < 5.1;
•6. Subjects with at least pain or swelling in both wrists;
•7. Patients who use hormones, hormone suspects or biological agents need to stop taking drugs for more than 3 months;
•8. Patients who did not use NSAIDs or topical analgesics at least one week before enrollment.
•9. Voluntary patients, signed informed consent.

•1. Patients with other rheumatic immune diseases, such as systemic lupus erythematosus, Sjogren's syndrome, severe osteoarthritis, etc;
•2. Patients with serious diseases such as cardiovascular, lung, liver, gastrointestinal tract, kidney, hematopoietic system or tumor, or complicated with various acute and chronic infections or other infectious diseases (hepatitis, tuberculosis, etc.);
•3. Subjects with local skin damage, infection or injury of the joints;
•4. Those patients who have no response to methotrexate and leflunomide;
•5. Patients with contraindications (pulmonary fibrosis, etc.) and allergic history of experimental drugs;
•6. Patients with history of alcohol abuse, drug abuse or neuropsychiatric disorders (epilepsy, depression, etc.);
•7. Pregnant or lactating women have a family planning in the near future;
•8. Patients who are participating in clinical research of other drugs.

发起方

The First Affiliated Hospital of Yunnan University of traditional Chinese Medicine