The Effect of Topical Agents in Cream Formations Containing Magnesium Sulfate on Wound Healing in the Rat Model
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 7th day evaluation
研究概览
简要总结
An experimental study examining wound healing in 5 different groups on 30 rats.
详细描述
Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 8 Weeks 至 12 Weeks（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •healthy rats between ages of 8- 12 weeks
排除标准
- •weight loss of more than 15% of body weight
研究组 & 干预措施
Group %1 mgso4
Cream containing 1% MgSO4 will be applied twice a day to 6 female rats.
干预措施: Experimental drug 1 (Other)
Group placebo
Isotonic solution will be administered daily to 6 female rats.
干预措施: placebo comparator (Other)
Group sham
Base cream to be applied twice a day to 6 female rats.
干预措施: sham comparator (Other)
Group %10 MgSO4
Cream containing 10% MgSO4 will be applied twice a day to 6 female rats.
干预措施: Experimental drug 2 (Other)
Group positive control
Cream containing centella asiatica will be applied twice a day to 6 female rats.
干预措施: Centella asiatica (Drug)
结局指标
主要结局
7th day evaluation
时间窗: 7th day
Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day.
次要结局
- 15th day evaluation(15th day)