A Field Deployable Blood Test for Stroke, Capable of Detecting Brain Ischaemia From the Earliest Stages of Pathology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 217
- 试验地点
- 2
- 主要终点
- To measure the levels of purine in the blood in Stroke patients compared to non-stroke patients (Healthy controls)
研究概览
简要总结
The hypothesis is that a stroke causes release of purines from brain into blood and that this is a very early biomarker of brain ischaemia. The investigators propose a simple blood test of substances (the purines) that result from cellular metabolism and are produced in excess when brain cells are starved of oxygen and glucose (as occurs during a stroke).
详细描述
In this study, the investigators propose to use newly developed biosensor technology (SMARTCap) to directly address whether purines are indicators of real strokes, and can distinguish strokes from other conditions with similar symptoms, more rapidly.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stroke patients: Admitted to the Hyperacute Stroke Unit having a suspected stroke within 1 hour of admission. Important to note that not all these patients will have suffered a stroke
- •Control participants: Relatives of patients admitted to the stroke treatment pathway, who are healthy and have no signs of cardiovascular illness
- •Healthy volunteers
排除标准
- •Stroke patients: Delay in admission exceeds the time window of 4 hours between stroke symptoms and admission
- •Control participants: Obvious signs or history of cerebrovascular disease
- •Unhealthy volunteers
结局指标
主要结局
To measure the levels of purine in the blood in Stroke patients compared to non-stroke patients (Healthy controls)
时间窗: 30 minutes down to 5 minutes
次要结局
- To identify ischaemic versus haemorrhagic strokes by combining purine measurements and CT scans(24 hours to 7 days)
研究者
Professor Christopher Imray
Professor Christopher Imray, Consultant Vascular Surgeon
University Hospitals Coventry and Warwickshire NHS Trust