Optimal Administration of Allopurinol in Dialysis Patients : A Chronotherapy Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in uric acid levels from baseline
研究概览
简要总结
Gout has a strong association with the metabolic syndrome, and it is often seen in patients with renal insufficiency. Allopurinol is a medication intended to lower uric acid and therefore prevents gout attacks. Its metabolism is mainly renal, and some evidence shows that it is also dialyzable. The hypothesis is that allopurinol would be more efficacious to lower uric acid if it was given after dialysis only. The investigators will then switch administration of allopurinol to bedtime for dialysis patients currently taking that medication.
详细描述
Gout has a strong association with the metabolic syndrome, and it is often seen in patients with renal insufficiency. A study has shown an incidence of fifteen percent of gout in the first five years spent in dialysis and it was associated with an increased mortality. Allopurinol is a medication intended to lower uric acid and therefore prevents gout attacks. Its metabolism is mainly renal, and some studies from the early 1960s demonstrated that it is also dialyzable. At the moment, we do not have strong evidence of the optimal dosage of allopurinol with modern techniques of dialysis. The hypothesis is that allopurinol would be more efficacious to lower uric acid if it was given after dialysis only. The investigators will then switch administration of allopurinol to bedtime for dialysis patients currently taking that medication. Dosage of uric acid will be performed to assess the efficacy of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who receive chronic treatments of hemodialysis at Maisonneuve-Rosemont Hospital
- •Subjects who take allopurinol for at least a month
排除标准
- •Subjects who have had an acute gout attack in the past month
- •Subjects with tumor lysis syndrome
- •Sujects who have a history of hypersensitivity reaction to allopurinol
- •Subjects with hepatic insufficiency
- •Women who are pregnant or planning to become pregnant in the next three months
研究组 & 干预措施
Allopurinol HS
Allopurinol at bedtime compared to AM administration
干预措施: Allopurinol (Drug)
结局指标
主要结局
Change in uric acid levels from baseline
时间窗: 6 weeks
Compare the efficacy of allopurinol when given before versus after dialysis
次要结局
未报告次要终点
研究者
Michel Vallée
Nephrologist, M.D., Ph.D., FRCP(C)
Maisonneuve-Rosemont Hospital