Pattern of Sickle Cell Nephropathy in Patients With Sickle Cell Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- sickle cell nephropathy in patient with sickle cell disease
研究概览
简要总结
There are some diseases that give rise to diverse renal manifestations as does sickle cell disease
详细描述
Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD.
Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease.
Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD.
Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Months 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with sickle cell anemia attending the unit will be included in the study.
排除标准
- •patient with any underlaying systemic diseases other than sickle cell anaemia
结局指标
主要结局
sickle cell nephropathy in patient with sickle cell disease
时间窗: one year
detection of renal impairment in patients with sickle cell disease by estamating gloerular and tubular dysfunction clinicaly and laboratory
次要结局
未报告次要终点
研究者
omnia talat hasan
assiut
Assiut University