ISRCTN12337078已完成未知
The effect of a single bout of high-intensity interval training on glucose responses in white European and South Asian patients at risk of type 2 diabetes
niversity of Leicester (UK)0 个研究点目标入组 24 人开始时间: 2015年5月20日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 16/05/2016:
- •1. Has had 2 hour glucose between 7.8mmol.L-1 and 11.1mmol.L-1 after an oral glucose tolerance test (performed at the Leicester Diabetes Centre as part of another study within 12 months)
- •Has HbA1c between 5.7% to 6.49% within the last 5 years
- •2. Is of south Asian (Indian, Bangladeshi, Pakistani) or white European (British, Irish or other European country) descent
- •3. Adults aged between 50 to 74 years inclusive (subject to females being post-menopausal defined as no menstruation in the last 12 months as reproductive hormones interact with appetite hormone responses)
- •4. Able to walk and use treadmill
- •5. BMI =27.5kg/m2 (WE) or =25kg/m2 (SA)
- •6. Weight stable (weight has not fluctuated more than ±5kg in the last 6 months)
- •7. Ability to communicate in and understand English to participate in the informed consent process
- •Previous inclusion criteria:
- •1. Has had 2 hour glucose between 7.8mmol.L-1 and 11.1mmol.L-1 after an oral glucose tolerance test (performed at the Leicester Diabetes Centre as part of another study within 12 months)
- •Has HbA1c between 6%-6.49% at baseline or at their most recent blood test within the previous 12 months
- •2. Is of south Asian (Indian, Bangladeshi, Pakistani) or white European (British, Irish or other European country) descent
- •3. Adults aged between 50 to 74 years inclusive (subject to females being post-menopausal defined as no menstruation in the last 12 months as reproductive hormones interact with appetite hormone responses)
- •4. Able to walk and use treadmill
- •5. BMI =27.5kg/m2 (WE) or =25kg/m2 (SA)
- •6. Weight stable (weight has not fluctuated more than ±5kg in the last 6 months)
- •7. Ability to communicate in and understand English to participate in the informed consent process
排除标准
- •Current exclusion criteria as of 16/05/2016:
- •1. Regular purposeful exercise (=3 x 20 minute bouts of self-reported vigorous exercise performed per week)
- •2. Individuals who stand for extended periods of time (standing has been shown to improve glycaemic variability)
- •3. Mixed race (including individuals of mixed race would prevent determination of whether ethnicity is a modifying factor in the response to HIT)
- •4. Use of any glucose lowering medication
- •5. Dieters/restrained eaters (as assessed using the 3 factor eating QA)
- •6. Any contraindications to exercise such as abnormal resting ECG, breathlessness or dizziness on exertion, poor circulation, hypo- or hypertension
- •7. Significant renal or hepatic impairment defining parameters i.e. chronic kidney disease stage 3b, liver markers more than 3x greater than the normal range
- •8. Consent not given to contact GP with test results
- •Previous exclusion criteria:
- •1. Diagnosed type 2 diabetes
- •2. Regular purposeful exercise (=3 x 20 minute bouts of self-reported vigorous exercise performed per week)
- •3. Individuals who stand for extended periods of time (standing has been shown to improve glycaemic variability)
- •4. Mixed race (including individuals of mixed race would prevent determination of whether ethnicity is a modifying factor in the response to HIT)
- •5. Use of any glucose lowering medication
- •6. Dieters/restrained eaters (as assessed using the 3 factor eating QA)
- •7. Any contraindications to exercise such as abnormal resting ECG, breathlessness or dizziness on exertion, poor circulation, hypo- or hypertension
- •8. Significant renal or hepatic impairment defining parameters i.e. chronic kidney disease stage 3b, liver markers more than 3x greater than the normal range
- •9. Consent not given to contact GP with test results
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