Virtual Reality for Cognitive Enhancement in Schizophrenia: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- The Loewenstein Occupational Therapy Cognitive Assessment (LOTCA)
研究概览
简要总结
This study was conducted to examine the effect of virtual reality intervention, given in addition to conventional occupational therapy intervention, on general cognitive functions (attention, orientation, memory, visual skills, visual-motor skills, praxis, executive functions, etc.) in individuals with schizophrenia. This study was designed in accordance with the CONSORT statement, which standardizes randomized controlled trials. Additionally, the study was approved by a university's scientific research ethics committee.
详细描述
This study was designed as a randomized controlled trial and conducted using the CONSORT checklist. Individuals who met the inclusion and exclusion criteria were included in the study. Both groups received traditional occupational therapy intervention, while the intervention group also received virtual reality intervention. All intervention procedures in the study were planned to take place three days a week for eight weeks, with each session lasting 45 minutes. A total of 114 individuals were included in the study; 54 were in the control group and 60 were in the intervention group.
Interventions
Conventional occupational therapy intervention approach was applied in both groups. The intervention group additionally received VR application with Microsoft Xbox 360 and Kinect. The interventions consisted of 45-minute sessions 3 days a week for 8 weeks. The intervention procedures are described in detail below and all interventions were performed by the last author of the study :
Conventional Occupational Therapy Intervention:
1-2. Week: Occupation-based interventions for visual skills Within the framework of the occupational therapy intervention calendar, in the first two weeks, participants were given training on visual memory, figure-ground perception, visual discrimination, visual completion, spatial perception, etc., which are the sub-parameters of visual perception skills. It is aimed to increase the visual skill levels of people by making interventions to improve the parameters. Response plan; As a result of the participants' occupation preferences and evaluation results, it was created and implemented using client-centered occupations that aim to increase people's visual skill levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) age between 18 and 65 years,
- •(2) Participants must have been diagnosed with Schizophrenia according to the ICD-10 diagnostic criteria,
- •(3) Participants must be able to read and write at a level that will allow them to understand the content of the study,
- •(4) There must be no severe cognitive impairment diagnosed that would prevent participation in the study,
- •(5) Participants' antipsychotic treatments must be stable (no medication changes in the last 3 months),
- •(6) Participants must be competent to provide informed consent
排除标准
- •(1) Existence of additional diagnoses such as schizoaffective disorder, bipolar disorder or severe depressive disorder,
- •(2) Existence of active substance or alcohol addiction diagnosed in the last 6 months,
- •(3) Presence of diseases that may affect cognitive functions such as epilepsy, dementia, Parkinson's disease,
- •(4) Exclusion of individuals who have active psychotic episodes or severe agitation during the study period,
- •(5) Exclusion of individuals who are at risk of harming themselves or others,
- •(6) For female participants, there is pregnancy or breastfeeding,
- •(7) There are conditions such as visual or hearing impairment that may prevent active participation
结局指标
主要结局
The Loewenstein Occupational Therapy Cognitive Assessment (LOTCA)
时间窗: 1 hour
The LOTCA is a performance test that consists of 20 items. The test includes testing materials such as card decks, colored blocks, a pegboard set, and other items. Additionally, a manual is provided that defines the cognitive domains assessed and provides administration instructions, and specific scoring guidelines. The LOTCA was scored on a Likert-type scale from 1 to 4, except for items 1-5 which related to categorization, unstructured Risk Object Classification, and structured Risk Object Classification. Higher scores indicate better cognitive functions
次要结局
未报告次要终点
研究者
Berkan Torpil, PhD
Assoc Prof
Saglik Bilimleri Universitesi