Improving Blood Pressure and Cardiovascular Risk With Resistance Exercise in African Americans
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Changes in peripheral and central blood pressure
研究概览
简要总结
After the participant meets all inclusion and exclusion criteria, they will be randomized equally to either the Resistance Training group (RT) or Aerobic Training group (AT). Both groups will participate in an 8 week initial control period, followed by 8 weeks of supervised exercise training, followed by 8 weeks of deconditioning. All participants will undergo the same assessments and procedures one time prior to the initial 8 week control period, and at each of the three periods. Assessments include: blood draws; arterial stiffness testing; ultrasounds of the brachial artery to measure flow-mediated dilation (FMD); gluteal adipose tissue biopsies; exercise testing to determine VO2 max; body composition analysis via DEXA scans; ambulatory blood pressure measurement; diet analysis via food journals; medical history questionnaires; urine analysis for pregnancy; and activity monitoring via accelerometer. Total participation will be 24-26 weeks.
详细描述
This study is divided into three separate 8-week periods, the Control period, the Exercise Training period and the De-training period. Testing sessions will be done at Week 0, Week 8, Week 16, and Week 24 of the study.
Control Period (weeks 0-8): Participants will have a control period of 8 weeks. Participants will be given a brochure regarding the benefits of regular exercise and nutrition on overall health.
- Baseline visit and eligibility assessment, Week 0: After an initial phone interview to screen participants for eligibility, participants will be scheduled for their two sessions of baseline assessments.
Randomization After the subject meets all inclusion and exclusion criteria, the participant will be randomized equally to either the Resistance Training group (RT) or Aerobic Training group (AT) with a table of random numbers by a staff member having no knowledge of the participant's baseline profile.
V1A (2 hours): Clinical Research Center and/or Integrative Physiology Lab
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sedentary
- •Body Mass Index of 18.5-40 kg/m²
- •Born in the United States of either two African-American or two non-Hispanic Caucasian parents
- •Blood pressure of at least 120/80 mmHg
排除标准
- •Inability to give informed consent
- •History of cardiovascular disease or cardiovascular events
- •Hypertension (systolic >159 mmHg and diastolic >99 mmHg) or on more than one anti-hypertensive medication
- •Diabetes Type I& II
- •Hyperlipidemia, with an LDL-C >159 mg/dL and /or total-C >229 mg/dL
- •Pregnancy (or intend to become pregnant while participating in study) or nursing
- •Tobacco use in the past 6 months (including, but not limited to cigarettes, e-cigarettes, hookah, Nicorette, SNUs and chewing tobacco)
- •Chronic inflammatory disease such as, but not limited to, cancer
- •Chronic autoimmune diseases such as, but not limited to: lupus, multiple sclerosis, rheumatoid arthritis
- •Adverse reaction to nitroglycerin
- •Anemia with a hemoglobin < 8
- •Head injury within last 6 months
- •Seizure disorder
- •Presence of renal disease with a creatinine > 1.5mg/dL
- •Presence of liver disease with liver enzymes > 3x the upper limits of normal
- •Currently abusing alcohol or illicit drugs
- •Unreliability as a study subject, in the opinion of the Investigator
- •Lidocaine allergy
- •Amenorrhea
- •Postmenopausal women
结局指标
主要结局
Changes in peripheral and central blood pressure
时间窗: Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24)
次要结局
- Changes in endothelial function(Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24))
- Changes in arterial stiffness(Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24))
研究者
Shane Phillips, PT, PhD
Professor
University of Illinois at Chicago