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临床试验/NCT00183144
NCT00183144已完成2 期

A Therapeutic Workplace for Alcohol Dependence

Johns Hopkins University2 个研究点 分布在 1 个国家目标入组 156 人开始时间: 2001年11月最近更新:
适应症

试验速览

阶段
2 期
状态
已完成
入组人数
156
试验地点
2
主要终点
percentage of 30 day assessments that subjects reported alcohol abstinence

研究概览

简要总结

The purpose of this study is to determine whether the Therapeutic Workplace is effective in increasing and maintaining long-term drug abstinence in homeless, alcohol dependent adults.

详细描述

Few populations are beset with the constellation of economic, social and health problems that afflict homeless individuals. At the heart of much of this misfortune are staggering rates of alcoholism and drug addiction. While it is not clear whether substance abuse is a cause, consequence, or simply a correlate of homelessness, there is no question that substance abuse is among the most common and most serious problems facing the homeless. Given their unique set of serious and chronic problems, the Institute of Medicine has identified the homeless as a group of people in need of specialized substance abuse interventions. Prior research has shown that the Therapeutic Workplace intervention is effective in the treatment of chronically unemployed heroin and cocaine dependent individuals. The intervention integrates abstinence reinforcement contingencies of proven efficacy into a model supported work program. Under this intervention, patients are paid to perform data entry jobs in the Therapeutic Workplace. Those lacking needed skills are given intensive training in basic academic and job skills. To reinforce abstinence from alcohol and drugs, patients are required to provide an alcohol-free breath sample and drug-free urine sample to gain entrance to the workplace each day. In this way, patients can work and earn salary only when they abstain from alcohol and drugs. Patients are paid in vouchers instead of cash to reduce the chance they will use their earnings to purchase alcohol or drugs.

A randomized trial was conducted to evaluate the efficacy of this intervention in homeless, alcohol-dependent adults who completed an inpatient alcohol detoxification. After the detoxification, 124 participants were invited to attend the workplace for 6 months. They were randomly assigned to one of three groups that differed in the requirements for voucher reinforcement. One group received the full therapeutic workplace intervention in which vouchers were contingent on both abstinence and work (Abstinence and Work group). A second group was paid for work, but did not have to provide an alcohol-free breath sample or drug-free urine sample to gain access to the workplace; their vouchers were contingent on work only (Work-Only group). A third group was invited to attend the therapeutic workplace but received no vouchers for work performed or abstinence achieved during treatment (No Voucher group).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • meet DSM IV criteria for alcohol dependence
  • are homeless in that they lack a fixed nighttime residence
  • are unemployed
  • are at least 18 years old

排除标准

  • are currently physically dependent on opioids
  • are considered in imminent risk of suicide
  • have a psychiatric disorder that is likely to result in behaviors that could disrupt the workplace functioning or limit their ability to provide informed consent
  • are physically unable to perform typing or keypad entry

结局指标

主要结局

percentage of 30 day assessments that subjects reported alcohol abstinence

percentage of heavy drinking days

percentage of positive breath-alcohol tests

percent of patients meeting criteria for current alcohol dependence

次要结局

  • percentage of urine samples negative for other drugs
  • percentage of participants employed each month
  • days employed per month
  • employment income per month

研究者

申办方类型
Other

研究点 (2)

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A Therapeutic Workplace for Alcohol Dependence | 临床试验