Aqueous Urea Concentration May be Related to Cataract Development
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Blood urea level
研究概览
简要总结
cataracts could be cured with eye drops. Some studies reported that in chronic renal failure, the occurrence of cataract is rare and the mechanism is unknown. The aim of this research is to describe correlation between urea concentration in the serum and aqueous humor and development of age related cataract.
详细描述
The study was conducted in the departments of Ophthalmology and internal medicine,
Asyut University hospitals, Egypt. Three groups of subjects were included:
patients with age related cortical cataracts who are otherwise healthy (cases) and two control groups; first systemically healthy subjects with ocular problems other than cataract and a second control group of patients with impaired renal functions and are not on dialysis treatment and thus have elevated serum urea levels. Slit lamp examination was performed to evaluate crystalline lens for opacities. Measurement of serum urea was done for all study subjects. Aqueous humor urea concentration was done only for the group of patients who are planned to have intraocular surgery. For that purpose, 0.1 ml of aqueous humor will be aspirated at the start of routine intraocular surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Senile Cortical cataract.
排除标准
- •Senile Nuclear cataract.
- •Congenital cataract
- •Traumatic cataract
结局指标
主要结局
Blood urea level
时间窗: 1 Day
The relation between blood urea level and cataract
次要结局
未报告次要终点
研究者
Hassan Lotfy Fahmy
Clinical Professor
Assiut University