NCT01376622已完成不适用
Changes in Pituitary Iron and Volume With Deferasirox in Transfusional Iron Overload
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
研究概览
简要总结
Despite continuing advances in iron chelation therapy, iron toxicity of endocrine glands, particularly the pituitary gland, remains common in patients with transfusion dependent anemias. We would like to establish accurate population norms of pituitary R2 and volume and understand the progression of pituitary iron in transfused patients on Deferasirox.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Currently on chronic transfusion therapy.
- •Duration of chronic transfusion >1 year.
- •Age 2 to 25 years
- •On deferasirox monotherapy for the duration of the study.
- •Informed consent from legal guardian and/or patient.
- •On deferasirox for a minimum of 3 months at start of study.
排除标准
- •Sickle cell disease or sickle-beta zero genotype.
- •Combination of deferasirox and another iron chelator.
研究者
John C. Wood
Principal Investigator
Children's Hospital Los Angeles
研究点 (1)
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