The Effect of a Single Training Session on Changes in Inflammatory, Hormonal, and Metabolic Markers in Athletes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- CK
研究概览
简要总结
The study aims to assess the acute response of wrestlers to a single training session. Short-term changes in inflammatory, hormonal, and metabolic markers are analyzed to assess fatigue development and recovery following intense exercise. Participation in the study involves completing a standard training session and providing blood samples at three time points to assess the physiological response. The results provide a better understanding of the mechanisms underlying adaptation to exercise in competitive wrestlers.
详细描述
The study aims to assess how wrestlers' bodies respond to a single, intense training session. The study focuses on short-term changes in markers of inflammation, the hormonal system (stress hormones, catecholamines), and the metabolic system. This enables a deeper understanding of the physiological mechanisms underlying fatigue development and post-exercise recovery.
Each participant will attend one standard training session, as outlined in the training plan. As part of the study, three venous blood samples will be collected:
- Before training - at rest, to determine baseline values;
- Immediately after training;
- 24 hours after exercise - to evaluate recovery processes.
Blood samples will be analyzed in the lab to determine:
- inflammatory markers (hsCRP, IL-6, TNF-α),
- muscle damage marker (CK),
- stress hormones (adrenaline, noradrenaline, cortisol),
- metabolic indicators (urea, creatinine, total protein, albumin, uric acid). The project does not require any additional supplementation, dietary changes, or modifications to the training plan.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Currently engaged in regular strength-endurance wrestling training.
- •Medically cleared for high-intensity exercise by a sports physician.
- •Willingness to participate and provide written informed consent.
- •Availability to attend the training session and all blood sampling time points (pre-training, immediately post-training, 24 hours post-training).
排除标准
- •Presence of acute or chronic illness that may affect exercise performance or physiological response.
- •Recent musculoskeletal injury limiting participation in high-intensity training.
- •Use of medications or supplements that may interfere with hormonal, inflammatory, or metabolic markers.
- •History of endocrine disorders, adrenal insufficiency, or other conditions affecting catecholamine or cortisol levels.
- •Inability or unwillingness to comply with study procedures.
结局指标
主要结局
CK
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Creatine kinase (CK)
Noradrenaline
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Noradrenaline
hsCRP
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
High-sensitivity C-reactive protein (hsCRP)
Concentration of high-sensitivity C-reactive protein (hsCRP)
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
High-sensitivity C-reactive protein (hsCRP) concentration will be measured to assess the inflammatory response.
Concentration of creatine kinase (CK)
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Creatine kinase (CK) concentration will be measured as a biomarker of muscle damage and the physiological response to the training session.
Concentration of tumor necrosis factor-alpha (TNF-α).
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Tumor necrosis factor-alpha (TNF-α) concentration will be assessed as a marker of the inflammatory response to training.
Concentration of interleukin-6 (IL-6).
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Interleukin-6 (IL-6) concentration will be assessed as a marker of the inflammatory response to training.
Concentration of adrenaline
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Adrenaline concentration will be assessed as a marker of the acute sympathoadrenal response to training.
Concentration of noradrenaline
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Noradrenaline concentration will be assessed as a marker of the acute sympathoadrenal response to training.
IL-6
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Interleukin-6
hsCRP
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
highly sensitive reactive C-protein
CK
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
creatine kinase
TNF-alpha
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Tumor necrosis factor-alpha (TNF-α)
A
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Adrenaline
Noradrenaline
时间窗: 1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.
Noradrenaline
次要结局
- TP(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Cortisol(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Concentration of cortisol(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Concentration of total protein.(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Concentration of urea.(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Concentration of albumin.(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Kortisol(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- TP(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Urea(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
- Albumin(1. Before training (at rest), 2. Immediately after training, 3. 24 hours after exercise.)
研究者
Anna Kasperska
Principal Investigator
Poznan University of Physical Education