Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3,338
- 试验地点
- 1
- 主要终点
- Depressed subjects at week 8 after delivery (EPDS and DSM I-V criteria for depression)
研究概览
简要总结
"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the infant.
Stressful life events, socio-demographic and obstetrical risk factors have been associated with the risk of PPD. Genetics risk factors of PPD have also been identified. We are presently studying for the first time how maternal stressors may interact with genetic factors to increase the risk of PPD (Gene x Environment interaction)".
详细描述
"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the infant.
Stressful life events, socio-demographic and obstetrical risk factors have been associated with the risk of PPD. Genetics risk factors of PPD have also been identified. We are presently studying for the first time how maternal stressors may interact with genetic factors to increase the risk of PPD (Gene x Environment interaction).
We want first to analyze the allelic association between SNPs of 5-HT, HPA and neurodevelopment genes and PPD with a case control association study We then analyse the interaction between maternal stressors during pregnancy and SNPS of our candidate genes (CRHR1, 5-HTT, TPH, BDNF, HMCN1).
3000 Caucasian mothers are included after pregnancy in 8 maternities and are evaluated at the inclusion, at 8 weeks and at 1 year with DIGS, FISC, EPDS and HAD, Stressful life events (Paykel). Blood are collected for all subjects for DNA extraction.
At week 8 and 1 year after pregnancy we search PPD with EDPS and DSM-IV criteria of depression".
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Caucasian mothers included after pregnancy (J0-J4)
排除标准
- •Age <18 years old, schizophrenia or mental retardation
结局指标
主要结局
Depressed subjects at week 8 after delivery (EPDS and DSM I-V criteria for depression)
时间窗: 8 weeks after delivery
Postnatal depression detected by a possible depression (EPDS score \> 8) and then confirmed (if EPDS score \> 8) by DIGS DSM-IV depression criteria.
次要结局
未报告次要终点